Neurobehavioural comorbidities of epilepsy: towards a network-based precision taxonomy
Cognitive and behavioural comorbidities are prevalent in childhood and adult epilepsies
and impose a substantial human and economic burden. Over the past century, the classic …
and impose a substantial human and economic burden. Over the past century, the classic …
Breakdown of spatial coding and interneuron synchronization in epileptic mice
Temporal lobe epilepsy causes severe cognitive deficits, but the circuit mechanisms remain
unknown. Interneuron death and reorganization during epileptogenesis may disrupt the …
unknown. Interneuron death and reorganization during epileptogenesis may disrupt the …
Evidence supporting deep brain stimulation of the medial septum in the treatment of temporal lobe epilepsy
Electrical brain stimulation has become an essential treatment option for more than one third
of epilepsy patients who are resistant to pharmacological therapy and are not candidates for …
of epilepsy patients who are resistant to pharmacological therapy and are not candidates for …
Functional neurophysiological biomarkers of early-stage Alzheimer's disease: A perspective of network hyperexcitability in disease progression
S Tok, A Ahnaou… - Journal of Alzheimer's …, 2022 - content.iospress.com
Network hyperexcitability (NH) has recently been suggested as a potential
neurophysiological indicator of Alzheimer's disease (AD), as new, more accurate biomarkers …
neurophysiological indicator of Alzheimer's disease (AD), as new, more accurate biomarkers …
Aged heterozygous Cdkl5 mutant mice exhibit spontaneous epileptic spasms
CDKL5 deficiency disorder (CDD) is a devastating neurodevelopmental disorder
characterized by early-onset epilepsy, severe intellectual disability, cortical visual …
characterized by early-onset epilepsy, severe intellectual disability, cortical visual …
Impaired θ-γ coupling indicates inhibitory dysfunction and seizure risk in a Dravet syndrome mouse model
Dravet syndrome (DS) is an epileptic encephalopathy that still lacks biomarkers for
epileptogenesis and its treatment. Dysfunction of Na V 1.1 sodium channels, which are …
epileptogenesis and its treatment. Dysfunction of Na V 1.1 sodium channels, which are …
Optogenetic “low‐theta” pacing of the septohippocampal circuit is sufficient for spatial goal finding and is influenced by behavioral state and cognitive demand
PR Mouchati, ML Kloc, GL Holmes, SL White… - …, 2020 - Wiley Online Library
Hippocampal theta oscillations show prominent changes in frequency and amplitude
depending on behavioral state or cognitive demands. How these dynamic changes in theta …
depending on behavioral state or cognitive demands. How these dynamic changes in theta …
Integration of the CA2 region in the hippocampal network during epileptogenesis
The CA2 pyramidal cells are mostly resistant to cell death in mesial temporal lobe epilepsy
(MTLE) with hippocampal sclerosis, but they are aberrantly integrated into the epileptic …
(MTLE) with hippocampal sclerosis, but they are aberrantly integrated into the epileptic …
Impaired spatial firing representations of neurons in the medial entorhinal cortex of the epileptic rat using microelectrode arrays
Z Xu, F Mo, G Yang, P Fan, B Lu, W Liang, F Kong… - Research, 2023 - spj.science.org
Epilepsy severely impairs the cognitive behavior of patients. It remains unclear whether
epilepsy-induced cognitive impairment is associated with neuronal activities in the medial …
epilepsy-induced cognitive impairment is associated with neuronal activities in the medial …
Network dysfunction in comorbid psychiatric illnesses and epilepsy
PLW Colmers, J Maguire - Epilepsy Currents, 2020 - journals.sagepub.com
The episodic nature of both epilepsy and psychiatric illnesses suggests that the brain
switches between healthy and pathological states. The most obvious example of transitions …
switches between healthy and pathological states. The most obvious example of transitions …