The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …

In addition to constituting the genetic material of an organism, DNA is a tracer for the
recognition of foreign pathogens and a trigger of the innate immune system. cGAS functions …

Besides its role as the blueprint of life, DNA can also alert the cell to the presence of
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …

Stimulator of interferon genes (STING) links innate immunity to biological processes ranging
from antitumor immunity to microbiome homeostasis. Mechanistic understanding of the …

Stimulator of interferon genes (STING) is a receptor in human cells that senses foreign cyclic
dinucleotides that are released during bacterial infection and in endogenous cyclic GMP …

Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

The stimulator of interferon genes (STING) is an endoplasmic reticulum transmembrane
protein that is a target of therapeutics for infectious diseases and cancer. However, early …

Host defense against viral pathogens is an essential function for all living organisms. In cell-
intrinsic innate immunity, dedicated sensor proteins recognize molecular signatures of …

Stimulator of interferon genes (STING) is a receptor in the endoplasmic reticulum that
propagates innate immune sensing of cytosolic pathogen-derived and self DNA. The …

Infections by pathogens that contain DNA trigger the production of type-I interferons and
inflammatory cytokines through cyclic GMP–AMP synthase, which produces 2′ 3′-cyclic …