Therapeutic targets for cardiac fibrosis: from old school to next-gen
Cardiovascular diseases remain the leading cause of death worldwide, with pathological
fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying …
fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying …
Pathophysiology and pharmacology of G protein-coupled receptors in the heart
G protein-coupled receptors (GPCRs), comprising the largest superfamily of cell surface
receptors, serve as fundamental modulators of cardiac health and disease owing to their key …
receptors, serve as fundamental modulators of cardiac health and disease owing to their key …
Recent advances in understanding the molecular pathophysiology of angiotensin II receptors; lessons from cell-selective receptor deletion in mice
The renin-angiotensin system (RAS) is an essential hormonal system involved in water and
sodium reabsorption, renal blood flow regulation, and arterial constriction. Systemic …
sodium reabsorption, renal blood flow regulation, and arterial constriction. Systemic …
Angiotensin II type 1A receptor expressed in smooth muscle cells is required for hypertensive vascular remodeling in mice infused with angiotensin II
K Okuno, K Torimoto, SM Cicalese, K Preston… - …, 2023 - Am Heart Assoc
Background: Ang II (angiotensin II) type 1 (AT1) receptors play a critical role in
cardiovascular diseases such as hypertension. Rodents have 2 types of AT1 receptor (AT1A …
cardiovascular diseases such as hypertension. Rodents have 2 types of AT1 receptor (AT1A …
Angiotensin receptors in the kidney and vasculature in hypertension and kidney disease
Kidney disease, blood pressure determination, hypertension pathogenesis, and the renin-
angiotensin system (RAS) are inextricably linked. Hence, understanding the RAS is pivotal …
angiotensin system (RAS) are inextricably linked. Hence, understanding the RAS is pivotal …
The immunology of heart failure with preserved ejection fraction
Heart failure with preserved ejection fraction (HFpEF) now accounts for the majority of new
heart failure diagnoses and continues to increase in prevalence in the United States …
heart failure diagnoses and continues to increase in prevalence in the United States …
Adaptive and maladaptive roles of different angiotensin receptors in the development of cardiac hypertrophy and heart failure
SK Bhullar, NS Dhalla - Canadian Journal of Physiology and …, 2023 - cdnsciencepub.com
Angiotensin II (Ang II) is formed by the action of angiotensin-converting enzyme (ACE) in the
renin–angiotensin system. This hormone is known to induce cardiac hypertrophy and heart …
renin–angiotensin system. This hormone is known to induce cardiac hypertrophy and heart …
A review of therapeutic strategies against cardiac fibrosis. From classical pharmacology to novel molecular, epigenetic, and biotechnological approaches
E Floris, C Cozzolino, S Marconi, F Tonicello… - Reviews in …, 2023 - iris.uniroma1.it
Cardiovascular diseases are the first cause of death worldwide, with a heavy social and
economic impact. They include a wide range of pathological conditions, among which …
economic impact. They include a wide range of pathological conditions, among which …
Pathophysiology of hypertension
JE Hall, ACM Omoto, Z Wang, A Mouton, X Li, ME Hall - Hypertension, 2024 - Elsevier
There is considerable blood pressure (BP) variability throughout the day, depending on
physical activity, stresses, and various environmental influences. These rapid changes in BP …
physical activity, stresses, and various environmental influences. These rapid changes in BP …
Infused juice concentrate of Japanese plum Prunus mume attenuates inflammatory vascular remodeling in a mouse model of hypertension induced by angiotensin II
K Okuno, K Torimoto, R Kuroda, SM Cicalese… - Hypertension …, 2023 - nature.com
Fruit from the Prunus mume tree is a traditional food in Japan. Recently, bainiku-ekisu, an
infused juice concentrate of Japanese Prunus mume, is attracting attention as a health …
infused juice concentrate of Japanese Prunus mume, is attracting attention as a health …