Ischemic stroke refers to the disorder of blood supply of local brain tissue caused by various
reasons. It has high morbidity and mortality worldwide. Astrocytes are the most abundant …

Central nervous system (CNS) myelination by oligodendrocytes (OLs) is a highly
orchestrated process involving well-defined steps from specification of neural stem cells into …

Astrocytes, the most abundant cell population in the central nervous system (CNS), are
essential for normal neurological function. We show that astrocytes are allocated to spatial …

The identity and degree of heterogeneity of glial progenitors and their contributions to brain
tumor malignancy remain elusive. By applying lineage-targeted single-cell transcriptomics …

Sphingosine 1-phosphate (S1P), a lysophospholipid, has gained relevance to multiple
sclerosis through the discovery of FTY720 (fingolimod), recently approved as an oral …

NG2 cells (also known as polydendrocytes) are a population of CNS cells that are distinct
from neurons, mature oligodendrocytes, astrocytes and microglia. They can be identified by …

Neurons have long held the spotlight as the central players of the nervous system, but we
must remember that we have equal numbers of astrocytes and neurons in the brain. Are …

Astrocytes as a cell population are not well defined and comprise a heterogeneous
population of cells. There are at least 9 different morphological variants which can coexist …

Highlights•Astrocytes play crucial roles in establishing neural circuits during
development.•The onset of astrogenesis is temporally regulated.•Extrinsic cues and intrinsic …

Despite their abundance, still little is known about the rather frequent, constantly proliferating
progenitors spread throughout the adult mouse brain parenchyma. The majority of these …