Cryo-EM structure of human voltage-gated sodium channel Nav1.6
Voltage-gated sodium channel Nav1. 6 plays a crucial role in neuronal firing in the central
nervous system (CNS). Aberrant function of Nav1. 6 may lead to epilepsy and other …
nervous system (CNS). Aberrant function of Nav1. 6 may lead to epilepsy and other …
Structural basis for human Cav3.2 inhibition by selective antagonists
The Cav3. 2 subtype of T-type calcium channels has been targeted for developing
analgesics and anti-epileptics for its role in pain and epilepsy. Here we present the cryo-EM …
analgesics and anti-epileptics for its role in pain and epilepsy. Here we present the cryo-EM …
Pathology of pain and its implications for therapeutic interventions
B Cao, Q Xu, Y Shi, R Zhao, H Li, J Zheng… - … and Targeted Therapy, 2024 - nature.com
Pain is estimated to affect more than 20% of the global population, imposing incalculable
health and economic burdens. Effective pain management is crucial for individuals suffering …
health and economic burdens. Effective pain management is crucial for individuals suffering …
Structural basis for human Cav1. 2 inhibition by multiple drugs and the neurotoxin calciseptine
Ca v 1.2 channels play crucial roles in various neuronal and physiological processes. Here,
we present cryo-EM structures of human Ca v 1.2, both in its apo form and in complex with …
we present cryo-EM structures of human Ca v 1.2, both in its apo form and in complex with …
Molecular insights into the gating mechanisms of voltage-gated calcium channel CaV2.3
Y Gao, S Xu, X Cui, H Xu, Y Qiu, Y Wei, Y Dong… - Nature …, 2023 - nature.com
High-voltage-activated R-type CaV2. 3 channel plays pivotal roles in many physiological
activities and is implicated in epilepsy, convulsions, and other neurodevelopmental …
activities and is implicated in epilepsy, convulsions, and other neurodevelopmental …
The Dysfunction of Ca2+ Channels in Hereditary and Chronic Human Heart Diseases and Experimental Animal Models
I Shemarova - International Journal of Molecular Sciences, 2023 - mdpi.com
Chronic heart diseases, such as coronary heart disease, heart failure, secondary arterial
hypertension, and dilated and hypertrophic cardiomyopathies, are widespread and have a …
hypertension, and dilated and hypertrophic cardiomyopathies, are widespread and have a …
[HTML][HTML] Benzo [a] pyrene represses synaptic vesicle exocytosis by inhibiting P/Q-type calcium channels in hippocampal neurons
YK Kim, Y Eom, H Yoon, Y Lee, SH Lee - Ecotoxicology and Environmental …, 2023 - Elsevier
Humans are exposed to the common carcinogen benzo [a] pyrene (BaP) by ingesting
contaminated foods and water or inhaling polluted air. Given the enriched lipids and …
contaminated foods and water or inhaling polluted air. Given the enriched lipids and …
Structural basis for different ω-agatoxin IVA sensitivities of the P-type and Q-type Cav2.1 channels
Dear Editor, Voltage-gated calcium (Cav) channels are essential for mediating Ca2+ influx
in response to membrane depolarization. Activation of Cav channels triggers fundamental …
in response to membrane depolarization. Activation of Cav channels triggers fundamental …
Structural biology of voltage-gated calcium channels
Voltage-gated calcium (Cav) channels mediate Ca2+ influx in response to membrane
depolarization, playing critical roles in diverse physiological processes. Dysfunction or …
depolarization, playing critical roles in diverse physiological processes. Dysfunction or …
Advancing Spinal Cord Stimulation-Exploring the Cellular Responses of Motor Neurons Through Patch-Clamp Electrophysiology (Video)| JoVE
Q Yao, X Luo, J Liu, L Li - JoVE (Journal of Visualized Experiments), 2023 - jove.com
Spinal cord stimulation (SCS) can effectively restore locomotor function after spinal cord
injury (SCI). Because the motor neurons are the final unit to execute sensorimotor behaviors …
injury (SCI). Because the motor neurons are the final unit to execute sensorimotor behaviors …