The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …
expression programmes. Significant advances have been made in understanding the …
Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine
C Xue, Q Chu, Q Zheng, S Jiang, Z Bao, Y Su… - Signal transduction and …, 2022 - nature.com
Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …
Epigenetic modification refers to heritable changes in the genetic material without any …
[HTML][HTML] Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging
Z Turi, M Lacey, M Mistrik, P Moudry - Aging (Albany NY), 2019 - ncbi.nlm.nih.gov
The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …
many factors and a huge energy investment from the cell. Ribosomes are essential for …
[HTML][HTML] Writers, readers and erasers of RNA modifications in cancer
R Esteve-Puig, A Bueno-Costa, M Esteller - Cancer letters, 2020 - Elsevier
Although cancer was originally considered a disease driven only by genetic mutations, it has
now been proven that it is also an epigenetic disease driven by DNA hypermethylation …
now been proven that it is also an epigenetic disease driven by DNA hypermethylation …
Dissecting the expression landscape of RNA-binding proteins in human cancers
B Kechavarzi, SC Janga - Genome biology, 2014 - Springer
Background RNA-binding proteins (RBPs) play important roles in cellular homeostasis by
controlling gene expression at the post-transcriptional level. Results We explore the …
controlling gene expression at the post-transcriptional level. Results We explore the …
RNA modification: mechanisms and therapeutic targets
L Qiu, Q Jing, Y Li, J Han - Molecular Biomedicine, 2023 - Springer
RNA modifications are dynamic and reversible chemical modifications on substrate RNA
that are regulated by specific modifying enzymes. They play important roles in the regulation …
that are regulated by specific modifying enzymes. They play important roles in the regulation …
Impact of microRNAs on regulatory networks and pathways in human colorectal carcinogenesis and development of metastasis
S Pizzini, A Bisognin, S Mandruzzato, M Biasiolo… - BMC genomics, 2013 - Springer
Background Qualitative alterations or abnormal expression of microRNAs (miRNAs) in colon
cancer have mainly been demonstrated in primary tumors. Poorly overlapping sets of …
cancer have mainly been demonstrated in primary tumors. Poorly overlapping sets of …
Epitranscriptomic signatures in lncRNAs and their possible roles in cancer
In contrast to the amazing exponential growth in knowledge related to long non-coding
RNAs (lncRNAs) involved in cell homeostasis or dysregulated pathological states, little is …
RNAs (lncRNAs) involved in cell homeostasis or dysregulated pathological states, little is …
RNA pseudouridylation in physiology and medicine: for better and for worse
M Penzo, AN Guerrieri, F Zacchini, D Treré… - Genes, 2017 - mdpi.com
Pseudouridine is the most abundant modification found in RNA. Today, thanks to next-
generation sequencing techniques used in the detection of RNA modifications …
generation sequencing techniques used in the detection of RNA modifications …
The role of RNA modification in hepatocellular carcinoma
Q Feng, D Wang, T Xue, C Lin, Y Gao, L Sun… - Frontiers in …, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) is a highly mortal type of primary liver cancer. Abnormal
epigenetic modifications are present in HCC, and RNA modification is dynamic and …
epigenetic modifications are present in HCC, and RNA modification is dynamic and …