Next-generation sequencing has made major strides in the past decade. Studies based on
large sequencing data sets are growing in number, and public archives for raw sequencing …

Data commons collate data with cloud computing infrastructure and commonly used
software services, tools, and applications to create biomedical resources for the large-scale …

Somatic mutations in cancer genomes are caused by multiple mutational processes each of
which generates a characteristic mutational signature. Using 84,729,690 somatic mutations …

Background The tumor microenvironment can be classified into immunologically active"
inflamed" tumors and inactive" non-inflamed" tumors based on the infiltration of cytotoxic …

Background Genomic rearrangements exert a heavy influence on the molecular landscape
of cancer. New analytical approaches integrating somatic structural variants (SSVs) with …

Recent studies demonstrated a dramatically increased risk of leukemia in patients with a
rare genetic disorder, Xeroderma Pigmentosum group C (XP-C), characterized by …

The binding of PRDM9 to chromatin is a key step in the induction of DNA double-strand
breaks associated with meiotic recombination hotspots; it is normally expressed solely in …

The vast amounts of genomic data now deposited in public repositories represent rich
resources for cancer researchers. Large‐scale genomics initiatives such as The Cancer …

One of the recommendations of the Cancer Moonshot Blue Ribbon Panel report from 2016
was the creation of a national cancer data ecosystem. We review some of the approaches …

Structural variants (SVs) are an important class of genetic variation implicated in a wide
array of genetic diseases including cancer. Despite the advances in whole genome …