Neutrophils, the most abundant and efficient defenders against pathogens, exert opposing
functions across cancer types. However, given their short half-life, it remains challenging to …

The heterogeneity and plasticity of neutrophils in tumor–host interactions and how tumor
signals induce reprogramming of neutrophil subpopulations need further investigation. Ng et …

Research into the mechanisms and manifestations of solid tumor vascularization was
launched more than 50 years ago with the proposition and experimental demonstrations that …

Tumor-associated macrophages (TAMs) are a heterogeneous population of cells whose
phenotypes and functions are shaped by factors that are incompletely understood. Herein …

Traditionally, neutrophils are perceived as terminally differentiated cells with defined
functions and limited plasticity. It is commonly believed that circulating, marginating and …

The aberrant glycosylation is a hallmark of cancer progression and chemoresistance. It is
also an immune therapeutic target for various cancers. Tunicamycin (TM) is one of the potent …

The tumor microenvironment is composed of tumor cells, stromal cells and leukocytes,
including innate and adaptive immune cells, and represents an ecological niche that …

Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages
with potent immunosuppressive activity. Numerous studies in mice and humans have …

Neutrophil infiltration occurs in a variety of liver diseases, but it is unclear how neutrophils
and hepatocytes interact. Neutrophils generally use granule proteases to digest …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a poor
prognosis and limited therapeutic options. Research on the tumor microenvironment (TME) …