The hyperdirect pathway (HDP) represents the main glutamatergic input to the subthalamic
nucleus (STN), through which the motor and prefrontal cerebral cortex can modulate basal …

Highlights•Apathy and impulsivity are common consequences of frontotemporal lobar
degeneration syndromes.•Common frontostriatal loops mediate different modes of apathy …

Optimal decision-making requires balancing fast but error-prone and more accurate but
slower decisions through adjustments of decision thresholds. Here, we demonstrate two …

Sequential sampling models such as the drift diffusion model (DDM) have a long tradition in
research on perceptual decision-making, but mounting evidence suggests that these models …

To identify knowledge gaps regarding new‐onset agitation and impulsivity prior to onset of
cognitive impairment or dementia the International Society to Advance Alzheimer's …

Impulse control disorders (ICDs) in Parkinson's disease (PD) have a high cumulative
incidence and negatively impact quality of life. ICDs are influenced by a complex interaction …

Recently, it has been proposed that similar to goal-directed and habitual action mediated by
the fronto-striatal circuits, the fronto-striato-subthalamic-pallidal-thalamo-cortical network …

Speed-accuracy trade-offs are often considered a confound in speeded choice tasks, but
individual differences in strategy have been linked to personality and brain structure. We ask …

The underpinning assumption of much research on cognitive individual differences (or
group differences) is that task performance indexes cognitive ability in that domain. In many …

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for
Parkinson's disease (PD). Varying the frequency DBS has differential effects on axial and …