Calcium signaling and cardiac arrhythmias
There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …
Mechanisms of Altered Ca2+ Handling in Heart Failure
M Luo, ME Anderson - Circulation research, 2013 - Am Heart Assoc
Ca2+ plays a crucial role in connecting membrane excitability with contraction in
myocardium. The hallmark features of heart failure are mechanical dysfunction and …
myocardium. The hallmark features of heart failure are mechanical dysfunction and …
Cardiac T-tubule microanatomy and function
Unique to striated muscle cells, transverse tubules (t-tubules) are membrane organelles that
consist of sarcolemma penetrating into the myocyte interior, forming a highly branched and …
consist of sarcolemma penetrating into the myocyte interior, forming a highly branched and …
The physiology and pathophysiology of T-tubules in the heart
In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …
important for triggering contraction by excitation-contraction (EC) coupling. These structures …
The role of junctophilin proteins in cellular function
SE Lehnart, XHT Wehrens - Physiological reviews, 2022 - journals.physiology.org
Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma
membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR) …
membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR) …
Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization
Objectives: This study sought to study the role of junctophilin-2 (JPH2) in atrial fibrillation
(AF). Background: JPH2 is believed to have an important role in sarcoplasmic reticulum (SR) …
(AF). Background: JPH2 is believed to have an important role in sarcoplasmic reticulum (SR) …
Emerging mechanisms of T-tubule remodelling in heart failure
Cardiac excitation–contraction coupling occurs primarily at the sites of transverse (T)-
tubule/sarcoplasmic reticulum junctions. The orderly T-tubule network guarantees the …
tubule/sarcoplasmic reticulum junctions. The orderly T-tubule network guarantees the …
Stimulated emission depletion live-cell super-resolution imaging shows proliferative remodeling of T-tubule membrane structures after myocardial infarction
E Wagner, MA Lauterbach, T Kohl, V Westphal… - Circulation …, 2012 - Am Heart Assoc
Rationale: Transverse tubules (TTs) couple electric surface signals to remote intracellular
Ca2+ release units (CRUs). Diffraction-limited imaging studies have proposed loss of TT …
Ca2+ release units (CRUs). Diffraction-limited imaging studies have proposed loss of TT …
Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca2+ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca2+ Dynamics
Rationale: Ca2+-induced Ca2+ release (CICR) in normal hearts requires close
approximation of L-type calcium channels (LTCCs) within the transverse tubules (T-tubules) …
approximation of L-type calcium channels (LTCCs) within the transverse tubules (T-tubules) …
EC coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator
INTRODUCTION Cardiac excitation-contraction (EC) coupling refers to a cascade of Ca2+-
mediated events whereby membrane depolarization leads to cell contraction. At the …
mediated events whereby membrane depolarization leads to cell contraction. At the …