Macrophage: a cell with many faces and functions in tuberculosis
Mycobacterium tuberculosis (Mtb) is the causative agent of human tuberculosis (TB) which
primarily infects the macrophages. Nearly a quarter of the world's population is infected …
primarily infects the macrophages. Nearly a quarter of the world's population is infected …
New insights into the mycobacterial PE and PPE proteins provide a framework for future research
LS Ates - Molecular microbiology, 2020 - Wiley Online Library
The PE and PPE proteins of Mycobacterium tuberculosis have been studied with great
interest since their discovery. Named after the conserved proline (P) and glutamic acid (E) …
interest since their discovery. Named after the conserved proline (P) and glutamic acid (E) …
Dual RNA-Seq of Mtb-infected macrophages in vivo reveals ontologically distinct host-pathogen interactions
Dissecting the in vivo host-pathogen interplay is crucial to understanding the molecular
mechanisms governing control or progression of intracellular infections. In this work, we …
mechanisms governing control or progression of intracellular infections. In this work, we …
Comprehensive analysis of iron utilization by Mycobacterium tuberculosis
L Zhang, RC Hendrickson, V Meikle… - PLoS …, 2020 - journals.plos.org
Iron is essential for nearly all bacterial pathogens, including Mycobacterium tuberculosis
(Mtb), but is severely limited in the human host. To meet its iron needs, Mtb secretes …
(Mtb), but is severely limited in the human host. To meet its iron needs, Mtb secretes …
Heme and hemoglobin utilization by Mycobacterium tuberculosis
Iron is essential for growth of Mycobacterium tuberculosis (Mtb), but most iron in the human
body is stored in heme within hemoglobin. Here, we demonstrate that the substrate-binding …
body is stored in heme within hemoglobin. Here, we demonstrate that the substrate-binding …
Transporters involved in the biogenesis and functionalization of the mycobacterial cell envelope
The biology of mycobacteria is dominated by a complex cell envelope of unique composition
and structure and of exceptionally low permeability. This cell envelope is the basis of many …
and structure and of exceptionally low permeability. This cell envelope is the basis of many …
Digerati–A multipath parallel hybrid deep learning framework for the identification of mycobacterial PE/PPE proteins
The genome of Mycobacterium tuberculosis contains a relatively high percentage (10%) of
genes that are poorly characterised because of their highly repetitive nature and high GC …
genes that are poorly characterised because of their highly repetitive nature and high GC …
Role of the PE/PPE family in host–pathogen interactions and prospects for anti-tuberculosis vaccine and diagnostic tool design
J Qian, R Chen, H Wang, X Zhang - Frontiers in cellular and infection …, 2020 - frontiersin.org
The pe/ppe genes are found in pathogenic, slow-growing Mycobacterium tuberculosis and
other M. tuberculosis complex (MTBC) species. These genes are considered key factors in …
other M. tuberculosis complex (MTBC) species. These genes are considered key factors in …
Mycobacterial PPE36 Modulates Host Inflammation by Promoting E3 Ligase Smurf1-Mediated MyD88 Degradation
Z Peng, Y Yue, S Xiong - Frontiers in Immunology, 2022 - frontiersin.org
Mycobacterium tuberculosis (Mtb) PPE36, a cell-wall-associated protein, is highly specific
and conserved for the Mtb complex group. Although PPE36 has been proven essential for …
and conserved for the Mtb complex group. Although PPE36 has been proven essential for …
DNA-Dependent Binding of Nargenicin to DnaE1 Inhibits Replication in Mycobacterium tuberculosis
MD Chengalroyen, MK Mason, A Borsellini… - ACS Infectious …, 2022 - ACS Publications
Natural products provide a rich source of potential antimicrobials for treating infectious
diseases for which drug resistance has emerged. Foremost among these diseases is …
diseases for which drug resistance has emerged. Foremost among these diseases is …