The DNA topoisomerase enzymes are essential to cell function and are found ubiquitously
in all domains of life. The various topoisomerase enzymes perform a wide range of functions …

Human DNA topoisomerase II is an important target in anticancer therapy. Despite the
clinical success of drugs that target topoisomerase II, the development of resistant cancer …

The extensive length, compaction, and interwound nature of DNA, together with its
controlled and restricted movement in eukaryotic cells, create a number of topological issues …

Although bacterial gyrase and topoisomerase IV have critical interactions with positively
supercoiled DNA, little is known about the actions of these enzymes on overwound …

DNA Topoisomerases (Topos) are ubiquitous nuclear enzymes involved in regulating the
topological state of DNA and, in eukaryotic organisms, Topos can be classified into two …

Organometallic compounds currently occupy an important place in the field of medicinal
inorganic chemistry due to the unique chemical properties of metal coordination …

To perform double-stranded DNA passage, type II topoisomerases generate a covalent
enzyme-cleaved DNA complex (ie cleavage complex). Although this complex is a requisite …

Thursday, February 25, 2021 221a sequences to superhelical apices. Base pair disruption
allows sharp bending at superhelical apices, which facilitates DNA writhing and, thus …

Type II topoisomerases are essential enzymes that modulate the topological state of DNA
supercoiling in all living organisms. These enzymes alter DNA topology by performing …

Topoisomerase II (TopoII) is an enzyme essential for cellular metabolism and replication as
it regulates DNA topology. Since inhibition of TopoII induces cell death, it is a well …