Regulation of TGF-β family signaling by inhibitory Smads
K Miyazawa, K Miyazono - Cold Spring Harbor …, 2017 - cshperspectives.cshlp.org
Inhibitory Smads (I-Smads) have conserved carboxy-terminal MH2 domains but highly
divergent amino-terminal regions when compared with receptor-regulated Smads (R …
divergent amino-terminal regions when compared with receptor-regulated Smads (R …
Smad-dependent and Smad-independent pathways in TGF-β family signalling
R Derynck, YE Zhang - Nature, 2003 - nature.com
Transforming growth factor-β (TGF-β) proteins regulate cell function, and have key roles in
development and carcinogenesis. The intracellular effectors of TGF-β signalling, the Smad …
development and carcinogenesis. The intracellular effectors of TGF-β signalling, the Smad …
Deubiquitination and stabilization of PD-L1 by CSN5
Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of
anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified …
anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified …
Signal transduction by the TGF-β superfamily
L Attisano, JL Wrana - Science, 2002 - science.org
Transforming growth factor–β (TGF-β) superfamily members regulate a plethora of
developmental processes, and disruption of their activity has been implicated in a variety of …
developmental processes, and disruption of their activity has been implicated in a variety of …
BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk
K Miyazono, S Maeda, T Imamura - Cytokine & growth factor reviews, 2005 - Elsevier
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-β (TGF-β)
superfamily, bind to two different serine/threonine kinase receptors, and mediate their …
superfamily, bind to two different serine/threonine kinase receptors, and mediate their …
Role of Smads in TGFβ signaling
CH Heldin, A Moustakas - Cell and tissue research, 2012 - Springer
Transforming growth factor-β (TGFβ) is the prototype for a large family of pleiotropic factors
that signal via heterotetrameric complexes of type I and type II serine/threonine kinase …
that signal via heterotetrameric complexes of type I and type II serine/threonine kinase …
Two major Smad pathways in TGF‐β superfamily signalling
K Miyazawa, M Shinozaki, T Hara, T Furuya… - Genes to …, 2002 - Wiley Online Library
Members of the transforming growth factor‐β (TGF‐β) superfamily bind to two different
serine/threonine kinase receptors, ie type I and type II receptors. Upon ligand binding, type I …
serine/threonine kinase receptors, ie type I and type II receptors. Upon ligand binding, type I …
To Ub or not to Ub: a regulatory question in TGF-β signaling
The transforming growth factor β (TGF-β) superfamily controls a wide spectrum of biological
processes in metazoans, including cell proliferation, apoptosis, differentiation, cell-fate …
processes in metazoans, including cell proliferation, apoptosis, differentiation, cell-fate …
The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells
Y Wang, Q Sun, N Mu, X Sun, Y Wang, S Fan… - Cell Communication and …, 2020 - Springer
Background Many cancers evade immune surveillance by overexpressing PD-L1. PD-L1
interacted with its receptor PD-1, resulting in reduction of T cell proliferation and activation …
interacted with its receptor PD-1, resulting in reduction of T cell proliferation and activation …
The COP9 signalosome
N Wei, XW Deng - Annual review of cell and developmental …, 2003 - annualreviews.org
▪ Abstract The COP9 signalosome (CSN) is composed of eight distinct subunits and is highly
homologous to the lid sub-complex of the 26S proteasome. CSN was initially defined as a …
homologous to the lid sub-complex of the 26S proteasome. CSN was initially defined as a …