Signaling pathways in obesity: mechanisms and therapeutic interventions

X Wen, B Zhang, B Wu, H Xiao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Wnt signaling mediates TLR pathway and promote unrestrained adipogenesis and metaflammation: therapeutic targets for obesity and type 2 diabetes

K Aamir, HU Khan, G Sethi, MA Hossain… - Pharmacological …, 2020 - Elsevier
Diabesity is the combination of type 2 diabetes and obesity characterized by chronic low-
grade inflammation. The Wnt signaling act as an evolutionary pathway playing crucial role in …

A diet high in sugar-sweetened beverage and low in fruits and vegetables is associated with adiposity and a pro-inflammatory adipokine profile

C Koebnick, MH Black, J Wu, YH Shu… - British Journal of …, 2018 - cambridge.org
Diet, obesity and adipokines play important roles in diabetes and CVD; yet, limited studies
have assessed the relationship between diet and multiple adipokines. This cross-sectional …

Integration of transcriptomics and non-targeted metabolomics reveals the underlying mechanism of skeletal muscle development in duck during embryonic stage

Z Hu, X Liu - International Journal of Molecular Sciences, 2023 - mdpi.com
Skeletal muscle is an important economic trait in duck breeding; however, little is known
about the molecular mechanisms of its embryonic development. Here, the transcriptomes …

A unifying hypothesis for control of body weight and reproduction in seasonally breeding mammals

G Helfer, P Barrett, PJ Morgan - Journal of neuroendocrinology, 2019 - Wiley Online Library
Animals have evolved diverse seasonal variations in physiology and reproduction to
accommodate yearly changes in environmental and climatic conditions. These changes in …

Activation of Wnt signaling in cortical neurons enhances glucose utilization through glycolysis

P Cisternas, P Salazar, C Silva-Álvarez… - Journal of Biological …, 2016 - ASBMB
The Wnt signaling pathway is critical for a number of functions in the central nervous system,
including regulation of the synaptic cleft structure and neuroprotection against injury …

Thermodynamics in gliomas: interactions between the canonical WNT/beta-catenin pathway and PPAR gamma

A Vallée, Y Lecarpentier, R Guillevin… - Frontiers in …, 2017 - frontiersin.org
Gliomas cells are the site of numerous metabolic and thermodynamics abnormalities with an
increasing entropy rate which is characteristic of irreversible processes driven by changes in …

The crosstalk of hedgehog, PI3K and Wnt pathways in diabetes

K Benchoula, IS Parhar, EH Wong - Archives of Biochemistry and …, 2021 - Elsevier
Hyperglycaemia causes pancreatic β-cells to release insulin that then attaches to a specific
expression of receptor isoform and reverses high glucose concentrations. It is well known …

Primary cilia as a signaling platform for control of energy metabolism

JH Choi, MS Kim - Diabetes & metabolism journal, 2018 - synapse.koreamed.org
Obesity has become a common healthcare problem worldwide. Cilia are tiny hair-like
organelles on the cell surface that are generated and anchored by the basal body. Non …

Leptin and chronic kidney diseases

S Mao, L Fang, F Liu, S Jiang, L Wu… - Journal of Receptors …, 2018 - Taylor & Francis
Chronic kidney diseases (CKD), a common outcome of various kidney diseases, cause a
series of refractory complications, which lead to great economic burdens on patients. The …