The metabolic reconfiguration of tumor cells constitutes a pivotal aspect of tumor
proliferation and advancement. This study delves into two primary facets of tumor …

Pancreatic ductal adenocarcinoma (PDA) is a lethal disease notoriously resistant to
therapy,. This is mediated in part by a complex tumour microenvironment, low vascularity …

Highlights•Nucleotide metabolism.•Tumor microenvironment.•Immune cells.•Cancer
therapy.•Immunotherapy.Nucleotide metabolism plays a crucial role in the regulation of the …

From our daily nutrition and synthesis within cells, nucleosides enter the bloodstream and
circulate throughout the body and tissues. Nucleosides and nucleotides are classically …

Metabolic dysfunction-associated fatty liver disease (MAFLD) has a global prevalence of
about 25% and no approved therapy. Using metabolomic and proteomic analyses, we …

Background The relationship between sodium-glucose cotransporter 2 (SGLT2) inhibitors
and prostate cancer is still unknown. Although these inhibitors can influence tumor …

Transporting and translating mRNAs in axons is crucial for neuronal viability. Local
synthesis of nuclear-encoded mitochondrial proteins protects long-lived axonal …

To rescue ischemic myocardium from progressing to myocardial infarction, timely
identification of the infarct size and reperfusion is crucial. However, fast and accurate …

The complexity of the tumor microenvironment (TME) is a crucial factor in lung
adenocarcinoma (LUAD) progression. To gain deeper insights into molecular mechanisms …

Mitochondria are semiautonomous organelles with diverse metabolic and cellular functions
including anabolism and energy production through oxidative phosphorylation. Following …