Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer's
disease have created excitement and have been heralded as corroboration of the amyloid …

“Medicinal cannabis” is defined as the use of cannabis-based products for the treatment of
an illness. Investigations of cannabis compounds in psychiatric and neurological illnesses …

The vascular basement membrane contributes to the integrity of the blood-brain barrier
(BBB), which is formed by brain capillary endothelial cells (BCECs). The BCECs receive …

As the field begins to test the concept of a" preclinical" stage of neurodegenerative disease,
when the pathophysiological process has begun in the brain, but clinical symptoms are not …

The pathophysiological process of Alzheimer's disease (AD) is thought to begin many years
before the diagnosis of AD dementia. This long “preclinical” phase of AD would provide a …

Oxidative stress is at the forefront of Alzheimer disease (AD) research. While its implications
in the characteristic neurodegeneration of AD are vast, the most important aspect is that it …

According to the free radical theory, aging can be considered as a progressive, inevitable
process partially related to the accumulation of oxidative damage into biomolecules–nucleic …

There is growing recognition that the pathophysiological process of Alzheimer disease (AD)
begins many years prior to clinically obvious symptoms, and the concept of a …

Since the earliest descriptions of Alzheimer's disease (AD), many theories have been
advanced as to its cause. These include:(1) exacerbation of aging,(2) degeneration of …

Alzheimer's disease (AD) is the most common cause of memory impairment and dementia in
the elderly. AD is pathologically characterized by extracellular deposits of beta-amyloid (Aβ) …