Cancer development is driven by the accumulation of alterations affecting the structure and
function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic …

Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …

We conducted the Reproducibility Project: Cancer Biology to investigate the replicability of
preclinical research in cancer biology. The initial aim of the project was to repeat 193 …

Gain-of-function mutations in isocitrate dehydrogenase (IDH) in human cancers result in the
production of d-2-hydroxyglutarate (d-2HG), an oncometabolite that promotes tumorigenesis …

The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central
metabolic pathway that performs the essential function of oxidizing nutrients to support …

As knowledge of cell metabolism has advanced, glutamine has been considered an
important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study …

The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

Mutations in the genes encoding the cytoplasmic and mitochondrial forms of isocitrate
dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently …

With rapid advances in sequencing technologies, tremendous progress has been made in
understanding the molecular pathogenesis of acute myeloid leukaemia (AML), thus …

Mitochondria are signaling organelles that regulate a wide variety of cellular functions and
can dictate cell fate. Multiple mechanisms contribute to communicate mitochondrial fitness to …