Transcriptional activation throughout the eukaryotic lineage has been tightly linked with
disruption of nucleosome organization at promoters, enhancers, silencers, insulators and …

Embryonic stem cells and induced pluripotent stem cells hold great promise for regenerative
medicine. These cells can be propagated in culture in an undifferentiated state but can be …

The analysis of exonic DNA from prostate cancers has identified recurrently mutated genes,
but the spectrum of genome-wide alterations has not been profiled extensively in this …

Although thousands of large intergenic non-coding RNAs (lincRNAs) have been identified in
mammals, few have been functionally characterized, leading to debate about their biological …

Malaria is caused by Plasmodium parasites that proliferate in the bloodstream. During each
replication cycle, some parasites differentiate into gametocytes, the only forms able to infect …

Naive embryonic stem cells hold great promise for research and therapeutics as they have
broad and robust developmental potential. While such cells are readily derived from mouse …

Prostate cancer is the second most common cause of male cancer deaths in the United
States. However, the full range of prostate cancer genomic alterations is incompletely …

Macromolecular assemblies that regulate chromatin structure using the energy of ATP
hydrolysis have critical roles in development, cancer, and stem cell biology. The ATPases of …

The possibility of safe discontinuation of therapy with nucleos (t) ide analogues (NAs)
remains one of the most controversial topics in the management of chronic hepatitis B …

New methods for the genome-wide analysis of chromatin are providing insight into its roles
in development and their underlying mechanisms. Current studies indicate that chromatin is …