Immune mechanisms in fibrotic pulmonary sarcoidosis
P Weeratunga, DR Moller, LP Ho - European Respiratory …, 2022 - Eur Respiratory Soc
Sarcoidosis is an immune-mediated disorder. Its immunopathology has been steadily
mapped out over the past few decades. Despite this, the underpinning mechanisms for …
mapped out over the past few decades. Despite this, the underpinning mechanisms for …
Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis
Sarcoidosis is an idiopathic inflammatory disorder that is commonly treated with
glucocorticoids. An imprecise understanding of the immunologic changes underlying …
glucocorticoids. An imprecise understanding of the immunologic changes underlying …
Th17. 1 cell driven sarcoidosis-like inflammation after anti-BCMA CAR T cells in multiple myeloma
Pseudo-progression and flare-up phenomena constitute a novel diagnostic challenge in the
follow-up of patients treated with immune-oncology drugs. We present a case study on …
follow-up of patients treated with immune-oncology drugs. We present a case study on …
Integrative single-cell analysis of cardiac and pulmonary sarcoidosis using publicly available cardiac and bronchoalveolar lavage fluid sequencing datasets
A Daoud, DA Lema, T Won, D Čiháková - Frontiers in Cardiovascular …, 2023 - frontiersin.org
Introduction Cardiac presentation of autoimmune sarcoidosis, known as cardiac sarcoidosis
(CS), is a poorly understood disease with high mortality and low diagnosis rate. While CS is …
(CS), is a poorly understood disease with high mortality and low diagnosis rate. While CS is …
Pentraxin 3 inhibits complement-driven macrophage activation to restrain granuloma formation in sarcoidosis
Rationale: Sarcoidosis is a multisystemic inflammatory disease characterized by the
formation of granulomas in response to persistent stimuli. The long pentraxin PTX3 …
formation of granulomas in response to persistent stimuli. The long pentraxin PTX3 …
Integrative bioinformatics analysis to explore a robust diagnostic signature and landscape of immune cell infiltration in sarcoidosis
M Duo, Z Liu, P Li, Y Wang, Y Zhang, S Weng… - Frontiers in …, 2022 - frontiersin.org
Background The unknown etiology of sarcoidosis with variable clinical features leads to
delayed diagnosis and limited therapeutic strategies. Hence, exploring the latent …
delayed diagnosis and limited therapeutic strategies. Hence, exploring the latent …
The landscape of transcriptomic and proteomic studies in sarcoidosis
Sarcoidosis is a systemic disease with gene/protein expression patterns that may be
different among different tissues, based on the presence or absence of granulomas, and on …
different among different tissues, based on the presence or absence of granulomas, and on …
[HTML][HTML] Application of laboratory models for sarcoidosis research
M Bhargava, ED Crouser - Journal of Autoimmunity, 2024 - Elsevier
This manuscript will review the implications and applications of sarcoidosis models towards
advancing our understanding of sarcoidosis disease mechanisms, identification of …
advancing our understanding of sarcoidosis disease mechanisms, identification of …
Single-Cell Transcriptomics of Mtb/HIV Co-Infection
Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) co-infection continues to pose
a significant healthcare burden. HIV co-infection during TB predisposes the host to the …
a significant healthcare burden. HIV co-infection during TB predisposes the host to the …
A fungal antigenic driver for Löfgren's syndrome sarcoidosis
CX Lim, T Weichhart - 2021 - rupress.org
Löfgren's syndrome is an acute form of sarcoidosis that is characterized by the activation of
CD4+ T helper cells. In this issue of JEM, Greaves et al.(2021. J. Exp. Med. https://doi …
CD4+ T helper cells. In this issue of JEM, Greaves et al.(2021. J. Exp. Med. https://doi …