A new era for understanding amyloid structures and disease
MG Iadanza, MP Jackson, EW Hewitt… - … reviews Molecular cell …, 2018 - nature.com
The aggregation of proteins into amyloid fibrils and their deposition into plaques and
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …
The activities of amyloids from a structural perspective
R Riek, DS Eisenberg - Nature, 2016 - nature.com
The aggregation of proteins into structures known as amyloids is observed in many
neurodegenerative diseases, including Alzheimer's disease. Amyloids are composed of …
neurodegenerative diseases, including Alzheimer's disease. Amyloids are composed of …
Targeting protein aggregation for the treatment of degenerative diseases
YS Eisele, C Monteiro, C Fearns… - Nature reviews Drug …, 2015 - nature.com
The aggregation of specific proteins is hypothesized to underlie several degenerative
diseases, which are collectively known as amyloid disorders. However, the mechanistic …
diseases, which are collectively known as amyloid disorders. However, the mechanistic …
Protein− nanoparticle interactions: opportunities and challenges
In recent years, the fabrication of nanomaterials and exploration of their properties have
attracted the attention of all branches of science, such as physics, chemistry, biology, and …
attracted the attention of all branches of science, such as physics, chemistry, biology, and …
Structure and aggregation mechanisms in amyloids
ZL Almeida, RMM Brito - Molecules, 2020 - mdpi.com
The aggregation of a polypeptide chain into amyloid fibrils and their accumulation and
deposition into insoluble plaques and intracellular inclusions is the hallmark of several …
deposition into insoluble plaques and intracellular inclusions is the hallmark of several …
Targeting biomolecular condensation and protein aggregation against cancer
Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …
separation, hold dichotomous roles in health and disease. Alongside their physiological …
Molecular mechanisms of amyloidosis
G Merlini, V Bellotti - New England Journal of Medicine, 2003 - Mass Medical Soc
Amyloidosis affects millions of people, as a cause of Alzheimer's disease or a complication
of dialysis, and also causes rare conditions. The many forms of the disorder have one …
of dialysis, and also causes rare conditions. The many forms of the disorder have one …
Theory and practice of size exclusion chromatography for the analysis of protein aggregates
Size exclusion chromatography (SEC) is a historical technique widely employed for the
detailed characterization of therapeutic proteins and can be considered as a reference and …
detailed characterization of therapeutic proteins and can be considered as a reference and …
Structural studies of amyloid proteins at the molecular level
DS Eisenberg, MR Sawaya - Annual review of biochemistry, 2017 - annualreviews.org
Dozens of proteins are known to convert to the aggregated amyloid state. These include
fibrils associated with systemic and neurodegenerative diseases and cancer, functional …
fibrils associated with systemic and neurodegenerative diseases and cancer, functional …
Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution
M Stefani, CM Dobson - Journal of molecular medicine, 2003 - Springer
The deposition of proteins in the form of amyloid fibrils and plaques is the characteristic
feature of more than 20 degenerative conditions affecting either the central nervous system …
feature of more than 20 degenerative conditions affecting either the central nervous system …