Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The brain is wired to predict future outcomes. Experience-dependent plasticity at excitatory
synapses within dopamine neurons of the ventral tegmental area, a key region for a broad …

Addiction is a disease of altered behavior. Addicts use drugs compulsively and will continue
to do so despite negative consequences. Even after prolonged periods of abstinence …

The last two decades have witnessed substantial advances in identifying synaptic plasticity
responsible for behavioral changes in animal models of substance use disorder. We have …

GluN3-containing NMDA receptors (GluN3-NMDARs) are rarer than the'classical'NMDARs,
which are composed solely of GluN1 and GluN2 subunits, and have non-conventional …

High rates of relapse to drug use during abstinence is a defining feature of human drug
addiction. This clinical scenario has been studied at the preclinical level using different …

NMDA-type glutamate receptors are ligand-gated ion channels that mediate a major
component of excitatory neurotransmission in the central nervous system (CNS). They are …

Current models of addiction and anxiety stem from the idea that aberrant function and
remodeling of neural circuits cause the pathological behaviors. According to this hypothesis …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

GluN3A is an atypical glycine-binding subunit of NMDA receptors (NMDARs) whose actions
in the brain are mostly unknown. Here, we show that the expression of GluN3A subunits …