Tumor growth is essentially the result of an evolving cross-talk between malignant and
surrounding stromal cells (fibroblasts, endothelial cells and inflammatory cells). This …

Communication between the cell and its surrounding environment, consisting of
proteinaceous (non-living material) and extracellular matrix (ECM), is important for …

Although many clinical studies have found a correlation of SPARC expression with
malignant progression and patient survival, the mechanisms for SPARC function in …

SPARC is a matricellular glycoprotein that mediates interactions between cells and their
microenvironment. It is produced at sites of tissue remodeling, where it regulates matrix …

Patients with melanoma metastatic to regional lymph nodes exhibit a range in tumor
progression, survival, and treatment. Current approaches to stratify patients with this stage of …

Cell migration and metastasis greatly contribute to the progression of tumors. Secreted
Protein and Rich in Cysteine SPARC, as a multi-faceted protein, is highly expressed in …

There is a growing socioeconomic recognition that clinical bone diseases such as bone
infections, bone tumors and osteoporotic bone loss mainly associated with ageing, are …

In melanoma, the extracellular protein SPARC (secreted protein acidic and rich in cysteine)
is related to tumor progression. Some of the evidence that links SPARC to melanoma …

Krüppel-Like Factor 4 (KLF4) functions as a tumor suppressor in some cancers, but its
molecular mechanism is not clear. Our recent study also showed that the expression of KLF4 …

Cancer is a complex disease with high incidence and mortality rates. The important role
played by the tumor microenvironment in regulating oncogenesis, tumor growth, and …