Organoid imaging: seeing development and function

R Keshara, YH Kim… - Annual review of cell and …, 2022 - annualreviews.org
Organoids are miniaturized and simplified versions of an organ produced in vitro from stem
or progenitor cells. They are used as a model system consisting of multiple cell types …

Biomechanical sensing using gas bubbles oscillations in liquids and adjacent technologies: Theory and practical applications

IS Maksymov, BQ Huy Nguyen, SA Suslov - Biosensors, 2022 - mdpi.com
Gas bubbles present in liquids underpin many natural phenomena and human-developed
technologies that improve the quality of life. Since all living organisms are predominantly …

Visible light-induced specific protein reaction delineates early stages of cell adhesion

R Rahikainen, SK Vester, P Turkki… - Journal of the …, 2023 - ACS Publications
Light is well-established for control of bond breakage but not for control of specific bond
formation in complex environments. We previously engineered the diffusion-limited reactivity …

Revealing single-neuron and network-activity interaction by combining high-density microelectrode array and optogenetics

T Kobayashi, K Shimba, T Narumi, T Asahina… - Nature …, 2024 - nature.com
The synchronous activity of neuronal networks is considered crucial for brain function.
However, the interaction between single-neuron activity and network-wide activity remains …

Mapping PTBP2 binding in human brain identifies SYNGAP1 as a target for therapeutic splice switching

JM Dawicki-McKenna, AJ Felix, EA Waxman… - Nature …, 2023 - nature.com
Alternative splicing of neuronal genes is controlled partly by the coordinated action of
polypyrimidine tract binding proteins (PTBPs). While PTBP1 is ubiquitously expressed …

Human cerebrospinal fluid affects chemoradiotherapy sensitivities in tumor cells from patients with glioblastoma

BW Stringer, MI De Silva, Z Greenberg… - Science …, 2023 - science.org
Cancers in the central nervous system resist therapies effective in other cancers, possibly
due to the unique biochemistry of the human brain microenvironment composed of …

Druggable transcriptomic pathways revealed in Parkinson's patient-derived midbrain neurons

M van den Hurk, S Lau, MC Marchetto… - npj Parkinson's …, 2022 - nature.com
Complex genetic predispositions accelerate the chronic degeneration of midbrain substantia
nigra neurons in Parkinson's disease (PD). Deciphering the human molecular makeup of PD …

Long-term adherence of human brain cells in vitro is enhanced by charged amine-based plasma polymer coatings

B Milky, M Zabolocki, SA Al-Bataineh, M van den Hurk… - Stem Cell Reports, 2022 - cell.com
Advances in cellular reprogramming have radically increased the use of patient-derived
cells for neurological research in vitro. However, adherence of human neurons on tissue …

[HTML][HTML] Loss of CNTNAP2 alters human cortical excitatory neuron differentiation and neural network development

F St George-Hyslop, M Haneklaus, T Kivisild… - Biological …, 2023 - Elsevier
Background Loss-of-function mutations in the contactin-associated protein-like 2
(CNTNAP2) gene are causal for neurodevelopmental disorders, including autism …

[HTML][HTML] More than a small adult brain: Lessons from chemotherapy-induced cognitive impairment for modelling paediatric brain disorders

MR Davies, Z Greenberg, DG van Vuurden… - Brain, Behavior, and …, 2024 - Elsevier
Childhood is recognised as a period of immense physical and emotional development, and
this, in part, is driven by underlying neurophysiological transformations. These …