Organoid imaging: seeing development and function
R Keshara, YH Kim… - Annual review of cell and …, 2022 - annualreviews.org
Organoids are miniaturized and simplified versions of an organ produced in vitro from stem
or progenitor cells. They are used as a model system consisting of multiple cell types …
or progenitor cells. They are used as a model system consisting of multiple cell types …
Biomechanical sensing using gas bubbles oscillations in liquids and adjacent technologies: Theory and practical applications
Gas bubbles present in liquids underpin many natural phenomena and human-developed
technologies that improve the quality of life. Since all living organisms are predominantly …
technologies that improve the quality of life. Since all living organisms are predominantly …
Visible light-induced specific protein reaction delineates early stages of cell adhesion
R Rahikainen, SK Vester, P Turkki… - Journal of the …, 2023 - ACS Publications
Light is well-established for control of bond breakage but not for control of specific bond
formation in complex environments. We previously engineered the diffusion-limited reactivity …
formation in complex environments. We previously engineered the diffusion-limited reactivity …
Revealing single-neuron and network-activity interaction by combining high-density microelectrode array and optogenetics
T Kobayashi, K Shimba, T Narumi, T Asahina… - Nature …, 2024 - nature.com
The synchronous activity of neuronal networks is considered crucial for brain function.
However, the interaction between single-neuron activity and network-wide activity remains …
However, the interaction between single-neuron activity and network-wide activity remains …
Mapping PTBP2 binding in human brain identifies SYNGAP1 as a target for therapeutic splice switching
JM Dawicki-McKenna, AJ Felix, EA Waxman… - Nature …, 2023 - nature.com
Alternative splicing of neuronal genes is controlled partly by the coordinated action of
polypyrimidine tract binding proteins (PTBPs). While PTBP1 is ubiquitously expressed …
polypyrimidine tract binding proteins (PTBPs). While PTBP1 is ubiquitously expressed …
Human cerebrospinal fluid affects chemoradiotherapy sensitivities in tumor cells from patients with glioblastoma
Cancers in the central nervous system resist therapies effective in other cancers, possibly
due to the unique biochemistry of the human brain microenvironment composed of …
due to the unique biochemistry of the human brain microenvironment composed of …
Druggable transcriptomic pathways revealed in Parkinson's patient-derived midbrain neurons
Complex genetic predispositions accelerate the chronic degeneration of midbrain substantia
nigra neurons in Parkinson's disease (PD). Deciphering the human molecular makeup of PD …
nigra neurons in Parkinson's disease (PD). Deciphering the human molecular makeup of PD …
Long-term adherence of human brain cells in vitro is enhanced by charged amine-based plasma polymer coatings
Advances in cellular reprogramming have radically increased the use of patient-derived
cells for neurological research in vitro. However, adherence of human neurons on tissue …
cells for neurological research in vitro. However, adherence of human neurons on tissue …
[HTML][HTML] Loss of CNTNAP2 alters human cortical excitatory neuron differentiation and neural network development
F St George-Hyslop, M Haneklaus, T Kivisild… - Biological …, 2023 - Elsevier
Background Loss-of-function mutations in the contactin-associated protein-like 2
(CNTNAP2) gene are causal for neurodevelopmental disorders, including autism …
(CNTNAP2) gene are causal for neurodevelopmental disorders, including autism …
[HTML][HTML] More than a small adult brain: Lessons from chemotherapy-induced cognitive impairment for modelling paediatric brain disorders
MR Davies, Z Greenberg, DG van Vuurden… - Brain, Behavior, and …, 2024 - Elsevier
Childhood is recognised as a period of immense physical and emotional development, and
this, in part, is driven by underlying neurophysiological transformations. These …
this, in part, is driven by underlying neurophysiological transformations. These …