Performance of nanoparticles for biomedical applications: The in vitro/in vivo discrepancy

S Berger, M Berger, C Bantz, M Maskos… - Biophysics Reviews, 2022 - pubs.aip.org
Nanomedicine has a great potential to revolutionize the therapeutic landscape. However, up-
to-date results obtained from in vitro experiments predict the in vivo performance of …

[HTML][HTML] Screening of the binding affinity of serum proteins to lipid nanoparticles in a cell free environment

F Sebastiani, MY Arteta, L Lindfors… - Journal of Colloid and …, 2022 - Elsevier
Lipid nanoparticles (LNPs) are promising drug and gene carriers. Upon intravenous
administration, LNPs' experience different degree of cellular uptake depending on their …

[HTML][HTML] SARS-CoV-2 spike protein removes lipids from model membranes and interferes with the capacity of high density lipoprotein to exchange lipids

Y Correa, S Waldie, M Thépaut, S Micciulla… - Journal of Colloid and …, 2021 - Elsevier
Cholesterol has been shown to affect the extent of coronavirus binding and fusion to cellular
membranes. The severity of Covid-19 infection is also known to be correlated with lipid …

[HTML][HTML] High-Density Lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner

Y Correa, R Del Giudice, S Waldie, M Thépaut… - Journal of Colloid and …, 2023 - Elsevier
There is a close relationship between the SARS-CoV-2 virus and lipoproteins, in particular
high-density lipoprotein (HDL). The severity of the coronavirus disease 2019 (COVID-19) is …

Expanding the Toolbox for Bicelle-Forming Surfactant–Lipid Mixtures

RD Giudice, N Paracini, T Laursen, C Blanchet… - Molecules, 2022 - mdpi.com
Bicelles are disk-shaped models of cellular membranes used to study lipid–protein
interactions, as well as for structural and functional studies on transmembrane proteins. One …

Deuteration for biological SANS: Case studies, success and challenges in chemistry and biology

AP Duff, M Cagnes, TA Darwish, AM Krause-Heuer… - Methods in …, 2022 - Elsevier
Small angle neutron scattering is a powerful complementary technique in structural biology.
It generally requires, or benefits from, deuteration to achieve its unique potentials. Molecular …

[PDF][PDF] Precise aminoethylene-based nanocarriers for dynamic nucleic acid delivery: A balancing act between polyplex stability and cargo release

S Berger - 2023 - edoc.ub.uni-muenchen.de
Therapeutic intervention at the genomic level offers various options for the preventive or
causal treatment of severe and life-threatening diseases such as viral infections, cancer, or …

Deuterated phospholipids to study the structure, function and dynamics of membrane proteins using neutron scattering

NR Yepuri, M Moir, AM Krause-Heuer, TA Darwish - 2021 - apo.ansto.gov.au
Contrast matching and contrast variation in neutron scattering provide unparalleled power
for understanding the structure, function, and dynamics of a selected component in a …