Current understanding of the molecular mechanisms of chemotherapy-induced peripheral neuropathy

X Chen, Y Gan, NPB Au, CHE Ma - Frontiers in Molecular …, 2024 - frontiersin.org
Chemotherapy-induced peripheral neuropathy (CIPN) is the most common off-target
adverse effects caused by various chemotherapeutic agents, such as cisplatin, oxaliplatin …

Overexpressed KCNK1 regulates potassium channels affecting molecular mechanisms and biological pathways in bladder cancer

W Zhang, XS Chen, Y Wei, XM Wang, XJ Chen… - European Journal of …, 2024 - Springer
This study aimed to explore the expression, molecular mechanism and its biological function
of potassium two pore domain channel subfamily K member 1 (KCNK1) in bladder cancer …

LncRNA Kcnq1ot1relieves neuropathic pain through downregulation of Myd88

D Li, C Yuan, B Zhao, G Cai, Y Xu - International Immunopharmacology, 2023 - Elsevier
Abstract Background Long non-coding RNAs (lncRNAs) have already been documented to
become the therapeutic targets for neuropathic pain. Here, this work focused on exploring …

The Potential Antinociceptive Effect and Mechanism of Cannabis sativa L. Extract on Paclitaxel-Induced Neuropathic Pain in Rats Uncovered by Multi-Omics Analysis

Y Xu, L Yao, Y Guo, C Shi, J Zhou, M Hua - Molecules, 2024 - mdpi.com
Cannabis sativa L.(hemp) is a herbaceous plant rich in cannabinoids with a long history of
use in pain treatment. The most well-characterized cannabinoids, cannabidiol (CBD) and Δ9 …

Single-Nuclei RNA Sequencing Identifies Type C Low-Threshold Mechanoreceptors as Key Players in Paclitaxel-Induced Peripheral Neuropathy

W Sun, R Li, X Zhang, S Wu, Y Jiang, Q Li, D Cao… - bioRxiv, 2024 - biorxiv.org
Neuropathic pain triggered by chemotherapy poses a significant clinical challenge.
Investigating cell type-specific alterations through single-cell transcriptome analysis holds …