The widespread availability of single-cell RNA sequencing (scRNA-seq) has led to the
development of new methods for understanding immune responses. Single-cell …

T cells exercise a multitude of functions such as cytotoxicity, secretion of immunomodulating
cytokines or regulation of tolerance, collectively resulting in an effective control of immune …

Assessment of single-cell gene expression (single-cell RNA sequencing) and adaptive
immune receptor (AIR) sequencing (scVDJ-seq) has been invaluable in studying …

The upper airway is an important site of infection, but immune memory in the human upper
airway is poorly understood, with implications for COVID-19 and many other human …

The mechanisms underlying the chronicity of autoimmune diseases of the central nervous
system (CNS) are largely unknown. In particular, it is unclear whether tissue-resident …

Existing approaches to therapeutic gene transfer are marred by the transient nature of gene
expression following non-integrative gene delivery and by safety concerns due to the …

B cells play an essential role in adaptive immunity and are intimately correlated with
pleiotropic immune-mediated diseases. Each B cell occupies a unique B cell receptor …

The capacity of humoral B cell-mediated immunity to effectively respond to and protect
against pathogenic infections is largely driven by the presence of a diverse repertoire of …

Single-cell T cell and B cell antigen receptor-sequencing data analysis can potentially
perform in-depth assessments of adaptive immune cells that inform on understanding …

Adaptive immune repertoires are composed by the ensemble of B and T-cell receptors
within an individual, reflecting both past and current immune responses. Recent advances in …