Alzheimer's disease (AD) is a highly heritable complex disease with no current effective
prevention or treatment. The majority of drugs developed for AD focus on the amyloid …

Highlights•More than 40 loci of interest have been associated with the risk of developing
AD.•Recent genetic data clearly implicate microglia as involved in the pathophysiological …

Technologies capable of programmable translation activation offer strategies to develop
therapeutics for diseases caused by insufficient gene expression. Here, we present …

Genome-wide association studies (GWAS) originally identified ATP-binding cassette, sub-
family A, member 7 (ABCA7), as a novel risk gene of Alzheimer's disease (AD). Since then …

Several studies, including genome wide association studies (GWAS), have strongly
suggested a central role for the ATP-binding cassette transporter subfamily A member 7 …

Clinical specialization is not only a force for progress, but it has also led to the fragmentation
of medical knowledge. The focus of research in the field of Alzheimer's disease (AD) is …

The ATP-binding cassette (ABC) reporter family functions to regulate the homeostasis of
phospholipids and cholesterol in the central nervous system, as well as peripheral tissues …

Premature termination codon (PTC) mutations in the ATP-Binding Cassette, Sub-Family A,
Member 7 gene (ABCA7) have recently been identified as intermediate-to-high penetrant …

The adenosine triphosphate–binding cassette subfamily A member 7 gene (ABCA7) is
associated with Alzheimer's disease (AD) in large genome-wide association studies …

Mutations leading to premature termination codons in ATP-Binding Cassette Subfamily A
Member 7 (ABCA7) are high penetrant risk factors of Alzheimer's disease (AD). The …