Nanogels and microgels are soft, deformable, and penetrable objects with an internal gel-
like structure that is swollen by the dispersing solvent. Their softness and the potential to …

Crossing the cellular membrane and delivering active pharmaceuticals or biologicals into
the cytosol of cells is an essential step in the development of nanomedicines. One of the …

Zwitterionic polymers by virtue of their unique chemical and physical attributes have
attracted researchers in recent years. The simultaneous presence of positive and negative …

Abstract Mutant KRAS sustained KRAS-GTP conformation and activated downstream
signaling in pancreatic cancer. Inhibition of KRAS expression has been widely utilized for …

Multifunctional hydrogels composed of segments with ionizable, hydrophilic, and
hydrophobic monomers have been optimized for sensing, bioseparation, and therapeutic …

Gene therapy can potentially treat a great number of diseases, from cancer to rare genetic
disorders. Very recently, the development and emergency approval of nucleic acid-based …

Gene therapy is a promising treatment for hereditary diseases, as well as acquired genetic
diseases, including cancer. Facing the complicated physiological and pathological …

Nanoparticles must recognize, adhere to, and/or traverse multiple barriers in sequence to
achieve cytosolic drug delivery. New nanoparticles often exhibit a unique ability to cross a …

In this work, pH-sensitive hydrogel nanoparticles based on N-isopropyl acrylamide (NIPAM)
and methacrylic acid (MAA) at various molar ratios, were synthesized and characterized in …

Poly (N‐isopropylacrylamide)(PNIPAM) is a versatile polymer known for its phase transition
properties, exhibiting a lower critical solution temperature (LCST) of approximately 32° C …