Providing metabolic support to neurons is now recognized as a major function of glial cells
that is conserved from invertebrates to vertebrates. However, research in this field has …

The accumulation of reactive oxygen species (ROS) is a common feature of tauopathies,
defined by Tau accumulations in neurons and glia. High ROS in neurons causes lipid …

Here, we reveal an unanticipated role of the blood-brain barrier (BBB) in regulating complex
social behavior in ants. Using scRNA-seq, we find localization in the BBB of a key hormone …

Parameters correlated with age and mortality in Drosophila melanogaster include
decreased negative geotaxis and centrophobism behaviors, decreased climbing and …

Glia is pivotal in regulating neuronal stem cell proliferation, functioning, and nervous system
homeostasis, significantly influencing neuronal health and disorders. Dysfunction in glial …

Lipid droplets (LDs) are dynamic organelles essential for lipid storage and organismal
survival. Studies have highlighted the importance of glial function in brain LD formation …

Acyl-CoA binding domain-containing proteins (ACBDs) perform diverse but often
uncharacterised functions linked to cellular lipid metabolism. Human ACBD4 and ACBD5 …

The translocator protein TSPO is an evolutionary conserved mitochondrial protein
overexpressed in various contexts of neurodegeneration. Friedreich Ataxia (FA) is a …

Lipid droplets serve as primary storage organelles for neutral lipids in neurons, glial cells,
and other cells in the nervous system. Lipid droplet formation begins with the synthesis of …

Organ-derived plasma protein signatures derived from aptamer protein arrays track organ-
specific aging, disease, and mortality in humans, but the robustness and clinical utility of …