Widely varied chemicals—including certain herbicides, plasticizers, drugs, and natural
products—induce peroxisome proliferation in rodent liver and other tissues. This …

Multiple lines of evidence implicate steroid hormone and growth factor cross-talk as a
modulator of endocrine response in breast cancer and that aberrations in growth factor …

Treatment of cells with the anti-cancer drug camptothecin (CPT) induces topoisomerase I
(Top1)-mediated DNA damage, which in turn affects cell proliferation and survival. In this …

The IGF pathway stimulates malignant behavior of breast cancer cells. Herein we identify the
mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) axis as a critical component of …

To determine the molecular mechanisms underlying the “cross talk” between the activity of 2,
3, 7, 8-tetra-chlorodibenzo-p-dioxin (TCDD), which binds to arylhydrocarbon receptor (AHR) …

Estrogen receptor (ER)-positive breast cancer, including luminal-A and-B, is the most
common type of breast cancer. Extended exposure to estrogen is associated with an …

Elevated levels of urokinase plasminogen activator-1 (uPA) and the insulin-like growth factor-
I receptor (IGF-IR) are associated with breast cancer recurrence and decreased survival. It is …

Correspondence to: RI Nicholson downstream signal transduction molecules such as MAP
kinase, which has been shown to activate ER possibly by a direct phosphorylation of serine …

Expression of the urokinase plasminogen activator (uPA) and its receptor (uPAR) correlates
with tumour cell invasiveness and helps to determine the prognosis of prostate and other …

Little is known about endogenous estrogen receptor β (ERβ) gene targets in human breast
cancer. We reported that estradiol (E 2) induces nuclear respiratory factor-1 (NRF-1) …