A putative G protein-coupled transmembrane polypeptide, named Pael receptor, was
identified as an interacting protein with Parkin, a gene product responsible for autosomal …

G protein–coupled receptors (GPCRs) are an evolutionarily conserved family of signaling
molecules comprising approximately 2% of the human genome; this receptor family remains …

The adrenergic system is an essential regulator of neuronal, endocrine, cardiovascular,
vegetative, and metabolic functions. The endogenous catecholamines epinephrine and …

In this review, subtypes of functional α1-adrenoceptor are discussed. These are cell
membrane receptors, belonging to the seven-transmembrane-spanning G-protein-linked …

The biological effects of epinephrine and norepinephrine are mediated via 9 different
adrenergic receptor subtypes, which all belong to the superfamily of G protein-coupled …

This article provides a brief review of the role of norepinephrine (NE) in epilepsy, starting
from early studies reproducing the kindling model in NE-lesioned rats, through the use of …

G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane
receptors and their signal transduction is tightly regulated by GPCR kinases (GRKs) and β …

α1‐Adrenoceptors are seven transmembrane domain GPCRs involved in numerous
physiological functions controlled by the endogenous catecholamines, noradrenaline and …

Amphetamine (AMPH) and methamphetamine (METH) are widely abused psychostimulants,
which produce a variety of psychomotor, autonomic and neurotoxic effects. The behavioral …

Cone snails have evolved many 1000s of small, structurally stable venom peptides
(conopeptides) for prey capture and defense. Whilst< 0.1% have been pharmacologically …