Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …
more than 500 million population worldwide. OA was believed to be caused by the wearing …
[HTML][HTML] ADAMTS and ADAM metalloproteinases in osteoarthritis–looking beyond the 'usual suspects'
CY Yang, A Chanalaris, L Troeberg - Osteoarthritis and cartilage, 2017 - Elsevier
Summary Introduction Matrix metalloproteinases (MMPs) and 'aggrecanase'a disintegrin
and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play …
and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play …
Age-related matrix stiffening epigenetically regulates α-Klotho expression and compromises chondrocyte integrity
Extracellular matrix stiffening is a quintessential feature of cartilage aging, a leading cause
of knee osteoarthritis. Yet, the downstream molecular and cellular consequences of age …
of knee osteoarthritis. Yet, the downstream molecular and cellular consequences of age …
[HTML][HTML] Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis
KM Fisch, R Gamini, O Alvarez-Garcia, R Akagi… - Osteoarthritis and …, 2018 - Elsevier
Objective Osteoarthritis (OA) is the most prevalent joint disease. As disease-modifying
therapies are not available, novel therapeutic targets need to be discovered and prioritized …
therapies are not available, novel therapeutic targets need to be discovered and prioritized …
The extracellular matrix of articular cartilage controls the bioavailability of pericellular matrix-bound growth factors to drive tissue homeostasis and repair
TL Vincent, O McClurg, L Troeberg - International Journal of Molecular …, 2022 - mdpi.com
The extracellular matrix (ECM) has long been regarded as a packing material; supporting
cells within the tissue and providing tensile strength and protection from mechanical stress …
cells within the tissue and providing tensile strength and protection from mechanical stress …
Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression
B Chan, M Glogauer, Y Wang, J Wrana, K Chan… - Science …, 2023 - science.org
In osteoarthritis (OA), a disease characterized by progressive articular cartilage degradation
and calcification, the articular chondrocyte phenotype changes and this correlates with actin …
and calcification, the articular chondrocyte phenotype changes and this correlates with actin …
[HTML][HTML] CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy
JM Zarebska, A Chanalaris, C Driscoll… - Osteoarthritis and …, 2017 - Elsevier
Objective The role of inflammation in structural and symptomatic osteoarthritis (OA) remains
unclear. One key mediator of inflammation is the chemokine CCL2, primarily responsible for …
unclear. One key mediator of inflammation is the chemokine CCL2, primarily responsible for …
Emerging players at the intersection of chondrocyte loss of maturational arrest, oxidative stress, senescence and low‐grade inflammation in osteoarthritis
M Minguzzi, S Cetrullo, S D'Adamo… - Oxidative medicine …, 2018 - Wiley Online Library
The prevalence of Osteoarthritis (OA) is increasing because of the progressive aging and
unhealthy lifestyle. These risk factors trigger OA by removing constraints that keep the tightly …
unhealthy lifestyle. These risk factors trigger OA by removing constraints that keep the tightly …
AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice
S Zhou, W Lu, L Chen, Q Ge, D Chen, Z Xu, D Shi… - Scientific Reports, 2017 - nature.com
Osteoarthritis (OA) is a progressive degenerative disease of the joints that is associated with
both joint injury and ageing. Here, we investigated the role of the energy sensor AMP …
both joint injury and ageing. Here, we investigated the role of the energy sensor AMP …
Exploring the translational potential of PLGA nanoparticles for intra-articular rapamycin delivery in osteoarthritis therapy
JC Ma, T Luo, B Feng, Z Huang, Y Zhang… - Journal of …, 2023 - Springer
Osteoarthritis (OA) is a prevalent joint disease that affects all the tissues within the joint and
currently lacks disease-modifying treatments in clinical practice. Despite the potential of …
currently lacks disease-modifying treatments in clinical practice. Despite the potential of …