Cellular pathways that repair chromosomal double-strand breaks (DSBs) have pivotal roles
in cell growth, development and cancer. These DSB repair pathways have been the target of …

Mutagenesis is a key hallmark and enabling characteristic of cancer cells, yet the diverse
underlying mutagenic mechanisms that shape cancer genomes are not understood. This …

Timely repair of chromosomal double-strand breaks is required for genome integrity and
cellular viability. The polymerase theta-mediated end joining pathway has an important role …

DNA polymerase θ belongs to the A family of DNA polymerases and plays a key role in DNA
repair and damage tolerance, including double-strand break repair and DNA translesion …

Background Although several key molecules have been identified to modulate SARS-CoV-2
invasion of human host cells, the molecules correlated with outcomes in COVID-19 caused …

POLD4 plays a crucial part in the complex machinery of DNA replication and repair as a vital
component of the DNA polymerase delta complex. In this research, we obtained original …

Saccharomyces cerevisiae DNA polymerase IV (Pol4) like its homolog, human DNA
polymerase lambda (Polλ), is involved in Non-Homologous End-Joining and Microhomology …

DNA strand breaks are repaired by DNA synthesis from an exposed DNA end paired with a
homologous DNA template. DNA polymerase delta (Pol δ) catalyses DNA synthesis in …

Double-strand breaks (DSBs) due to genotoxic stress represent potential threats to genome
stability. Dysfunctional telomeres are recognized as DSBs and are repaired by distinct DNA …

Recent structural analysis of Fe-S centers in replication proteins and insights into the
structure and function of DNA polymerase δ (DNA Pol δ) subunits have shed light on the key …