Extracellular vesicle analysis

A Hendrix, L Lippens, C Pinheiro, C Théry… - Nature Reviews …, 2023 - nature.com
Cells release small, phospholipid membrane-enclosed particles, collectively referred to as
extracellular vesicles (EVs), into their surroundings to enable intercellular communication …

[HTML][HTML] The role of vaccines in combatting antimicrobial resistance

F Micoli, F Bagnoli, R Rappuoli, D Serruto - Nature Reviews …, 2021 - nature.com
The use of antibiotics has enabled the successful treatment of bacterial infections, saving the
lives and improving the health of many patients worldwide. However, the emergence and …

Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology

K Cheng, R Zhao, Y Li, Y Qi, Y Wang, Y Zhang… - Nature …, 2021 - nature.com
An effective tumor vaccine vector that can rapidly display neoantigens is urgently needed.
Outer membrane vesicles (OMVs) can strongly activate the innate immune system and are …

Sexually transmitted infections and female reproductive health

OT Van Gerwen, CA Muzny, JM Marrazzo - Nature microbiology, 2022 - nature.com
Women are disproportionately affected by sexually transmitted infections (STIs) throughout
life. In addition to their high prevalence in women, STIs have debilitating effects on female …

Infection microenvironment-related antibacterial nanotherapeutic strategies

Z Wang, X Liu, Y Duan, Y Huang - Biomaterials, 2022 - Elsevier
The emergence and spread of antibiotic resistance is one of the biggest challenges in public
health. There is an urgent need to discover novel agents against the occurrence of multidrug …

Nanocarriers based on bacterial membrane materials for cancer vaccine delivery

X Zhao, R Zhao, G Nie - Nature protocols, 2022 - nature.com
Here we present a protocol for the construction and use of two types of nanocarrier based on
bacterial membrane materials for cancer vaccine delivery. Cancer vaccines induce tumor …

Effectiveness of a serogroup B outer membrane vesicle meningococcal vaccine against gonorrhoea: a retrospective observational study

WE Abara, KT Bernstein, FMT Lewis… - The Lancet Infectious …, 2022 - thelancet.com
Background Declining antimicrobial susceptibility to current gonorrhoea antibiotic treatment
and inadequate treatment options have raised the possibility of untreatable gonorrhoea …

Diagnosis and treatment of sexually transmitted infections: a review

S Tuddenham, MM Hamill, KG Ghanem - Jama, 2022 - jamanetwork.com
Importance Approximately 1 in 5 adults in the US had a sexually transmitted infection (STI) in
2018. This review provides an update on the epidemiology, diagnosis, and treatment of …

Bacterial Outer Membrane Vesicles Presenting Programmed Death 1 for Improved Cancer Immunotherapy via Immune Activation and Checkpoint Inhibition

Y Li, R Zhao, K Cheng, K Zhang, Y Wang, Y Zhang… - ACS …, 2020 - ACS Publications
Natural, extracellular membrane vesicles secreted by Gram-negative bacteria, outer
membrane vesicles (OMVs), contain numerous pathogen-associated molecular patterns …

Biomimetic nanotechnology toward personalized vaccines

J Zhou, AV Kroll, M Holay, RH Fang… - Advanced …, 2020 - Wiley Online Library
While traditional approaches for disease management in the era of modern medicine have
saved countless lives and enhanced patient well‐being, it is clear that there is significant …