Metastatic progression combined with non-responsiveness towards systemic therapy often
shapes the course of disease for cancer patients and commonly determines its lethal …

Acute inflammation or resolved inflammation is an adaptive host defense mechanism and is
self-limiting, which returns the body to a state of homeostasis. However, unresolved …

Background Concomitant medications, such as steroids, proton pump inhibitors (PPI) and
antibiotics, might affect clinical outcomes with immune checkpoint inhibitors. Methods We …

Simple Summary Proteolytic enzymes, such as matrix metalloproteinases, plasminogen
activators and cathepsins, as well as non-proteolytic enzymatic partners, such as …

Heparanase, the sole heparan sulfate (HS)-degrading endoglycosidase, regulates multiple
biological activities that enhance tumor growth, metastasis, angiogenesis, and inflammation …

The nonsteroidal anti‐inflammatory agent aspirin is widely used for preventing and treating
cardiovascular and cerebrovascular diseases. In addition, epidemiologic evidences reveal …

Exosomes from extracellular vesicles can activate or inhibit various signaling pathways by
transporting proteins, lipids, nucleic acids and other substances to recipient cells. In …

Sepsis is a dysregulated systemic inflammatory response caused by infection that leads to
multiple organ injury and high mortality without effective treatment. Corilagin, a natural …

Heparanase is an endoglycosidase involved in remodeling the extracellular matrix and
thereby in regulating multiple cellular processes and biological activities. It cleaves heparan …

Background Whether aspirin use can decrease or increase cancer risk remains
controversial. In this study, a meta-analysis of cohort studies and randomized controlled …