Status and prospects of genome‐wide association studies in plants

L Tibbs Cortes, Z Zhang, J Yu - The plant genome, 2021 - Wiley Online Library
Genome‐wide association studies (GWAS) have developed into a powerful and ubiquitous
tool for the investigation of complex traits. In large part, this was fueled by advances in …

Salt Reduction to Prevent Hypertension and Cardiovascular Disease: JACC State-of-the-Art Review

FJ He, M Tan, Y Ma, GA MacGregor - Journal of the American College of …, 2020 - jacc.org
There is strong evidence for a causal relationship between salt intake and blood pressure.
Randomized trials demonstrate that salt reduction lowers blood pressure in both individuals …

The gut microbiome in atherosclerotic cardiovascular disease

Z Jie, H Xia, SL Zhong, Q Feng, S Li, S Liang… - Nature …, 2017 - nature.com
The gut microbiota has been linked to cardiovascular diseases. However, the composition
and functional capacity of the gut microbiome in relation to cardiovascular diseases have not …

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

L Hoyles, JM Fernández-Real, M Federici, M Serino… - Nature medicine, 2018 - nature.com
Hepatic steatosis is a multifactorial condition that is often observed in obese patients and is
a prelude to non-alcoholic fatty liver disease. Here, we combine shotgun sequencing of fecal …

Proteomics: technologies and their applications

B Aslam, M Basit, MA Nisar, M Khurshid… - Journal of …, 2016 - academic.oup.com
Proteomics involves the applications of technologies for the identification and quantification
of overall proteins present content of a cell, tissue or an organism. It supplements the other …

[HTML][HTML] Metabolite interactions between host and microbiota during health and disease: Which feeds the other?

Y Zhang, R Chen, DD Zhang, S Qi, Y Liu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Metabolites produced by the host and microbiota play a crucial role in how human bodies
develop and remain healthy. Most of these metabolites are produced by microbiota and …

Genetic determinants of the gut microbiome in UK twins

JK Goodrich, ER Davenport, M Beaumont… - Cell host & …, 2016 - cell.com
Studies in mice and humans have revealed intriguing associations between host genetics
and the microbiome. Here we report a 16S rRNA-based analysis of the gut microbiome in …

The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation

A Langdon, N Crook, G Dantas - Genome medicine, 2016 - Springer
The widespread use of antibiotics in the past 80 years has saved millions of human lives,
facilitated technological progress and killed incalculable numbers of microbes, both …

The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level

W Barton, NC Penney, O Cronin, I Garcia-Perez… - Gut, 2018 - gut.bmj.com
Objective It is evident that the gut microbiota and factors that influence its composition and
activity effect human metabolic, immunological and developmental processes. We …

Quantitative serum nuclear magnetic resonance metabolomics in large-scale epidemiology: a primer on-omic technologies

P Würtz, AJ Kangas, P Soininen… - American journal of …, 2017 - academic.oup.com
Detailed metabolic profiling in large-scale epidemiologic studies has uncovered novel
biomarkers for cardiometabolic diseases and clarified the molecular associations of …