Could polygenic risk scores be useful in psychiatry?: a review
Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibility to
diseases, calculated for individuals as weighted counts of thousands of risk variants in which …
diseases, calculated for individuals as weighted counts of thousands of risk variants in which …
[HTML][HTML] From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators
H Han, B Yi, R Zhong, M Wang, S Zhang, J Ma, Y Yin… - Microbiome, 2021 - Springer
Feelings of hunger and satiety are the key determinants for maintaining the life of humans
and animals. Disturbed appetite control may disrupt the metabolic health of the host and …
and animals. Disturbed appetite control may disrupt the metabolic health of the host and …
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
N Mullins, AJ Forstner, KS O'Connell, B Coombes… - Nature …, 2021 - nature.com
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …
Interpreting type 1 diabetes risk with genetics and single-cell epigenomics
Genetic risk variants that have been identified in genome-wide association studies of
complex diseases are primarily non-coding. Translating these risk variants into mechanistic …
complex diseases are primarily non-coding. Translating these risk variants into mechanistic …
[HTML][HTML] Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders
Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying
susceptibility genes could highlight the underlying pathophysiological mechanisms. We …
susceptibility genes could highlight the underlying pathophysiological mechanisms. We …
Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis
We interrogate the joint genetic architecture of 11 major psychiatric disorders at
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …
Genetics and neurobiology of eating disorders
Eating disorders (anorexia nervosa, bulimia nervosa and binge-eating disorder) are a
heterogeneous class of complex illnesses marked by weight and appetite dysregulation …
heterogeneous class of complex illnesses marked by weight and appetite dysregulation …
Shared heritability of human face and brain shape
Evidence from model organisms and clinical genetics suggests coordination between the
developing brain and face, but the role of this link in common genetic variation remains …
developing brain and face, but the role of this link in common genetic variation remains …
[HTML][HTML] Cognitive interpersonal model for anorexia nervosa revisited: The perpetuating factors that contribute to the development of the severe and enduring illness
The cognitive interpersonal model was outlined initially in 2006 in a paper describing the
valued and visible aspects of anorexia nervosa (Schmidt and Treasure, 2006). In 2013, we …
valued and visible aspects of anorexia nervosa (Schmidt and Treasure, 2006). In 2013, we …
The genetic architecture of depression in individuals of East Asian ancestry: a genome-wide association study
O Giannakopoulou, K Lin, X Meng, MH Su… - JAMA …, 2021 - jamanetwork.com
Importance Most previous genome-wide association studies (GWAS) of depression have
used data from individuals of European descent. This limits the understanding of the …
used data from individuals of European descent. This limits the understanding of the …