[HTML][HTML] The immune system is a natural target for estrogen action: opposing effects of estrogen in two prototypical autoimmune diseases

D Khan, S Ansar Ahmed - Frontiers in immunology, 2016 - frontiersin.org
Analogous to other physiological systems, the immune system also demonstrates
remarkable sex differences. Although the reasons for sex differences in immune responses …

[HTML][HTML] Autoimmune disease in women: endocrine transition and risk across the lifespan

MK Desai, RD Brinton - Frontiers in endocrinology, 2019 - frontiersin.org
Women have a higher incidence and prevalence of autoimmune diseases than men, and
85% or more patients of multiple autoimmune diseases are female. Women undergo …

Sex and gender issues in multiple sclerosis

HF Harbo, R Gold, M Tintoré - Therapeutic advances in …, 2013 - journals.sagepub.com
Multiple sclerosis (MS) is universally found to be more prevalent in women than men. This
has led to extensive studies of differences in the immune system or nervous system between …

Impact of sex hormones on immune function and multiple sclerosis development

MC Ysrraelit, J Correale - Immunology, 2019 - Wiley Online Library
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) affecting young people and leading to demyelination and neurodegeneration. The …

Fetomaternal immune cross-talk and its consequences for maternal and offspring's health

PC Arck, K Hecher - Nature medicine, 2013 - nature.com
An improved mechanistic understanding of the adaptational processes mounted during
mammalian reproduction is emerging. Intricate pathways occurring at the fetomaternal …

[HTML][HTML] Anti-CD20 therapies in multiple sclerosis: From pathology to the clinic

J de Sèze, E Maillart, A Gueguen, DA Laplaud… - Frontiers in …, 2023 - frontiersin.org
The immune system plays a significant role in multiple sclerosis. While MS was historically
thought to be T cell-mediated, multiple pieces of evidence now support the view that B cells …

[HTML][HTML] Early aggressive treatment approaches for multiple sclerosis

A Simpson, EM Mowry, SD Newsome - Current treatment options in …, 2021 - Springer
Purpose of review This review presents a comprehensive analysis of the current high-
efficacy disease-modifying therapies (DMTs) available for treatment of multiple sclerosis …

Sex affects immunity

LM Pennell, CL Galligan, EN Fish - Journal of autoimmunity, 2012 - Elsevier
Sex based differences in immune responses, affecting both the innate and adaptive immune
responses, contribute to differences in the pathogenesis of infectious diseases in males and …

The epidemiology of multiple sclerosis: insights to disease pathogenesis

DS Goodin - Handbook of clinical neurology, 2014 - Elsevier
The purpose of studying the epidemiology of multiple sclerosis (MS) is twofold. First, it is
important to understand clearly the natural history of the illness in order to assist patients in …

Sex-related factors in multiple sclerosis susceptibility and progression

RR Voskuhl, SM Gold - Nature Reviews Neurology, 2012 - nature.com
The pathogenesis of multiple sclerosis (MS) involves complex interactions between genetic
susceptibility and environmental triggers. Clinical observations suggest that the study of sex …