Abstract Glycogen phosphorylase (GP)(EC 2.4. 1.1) is an important therapeutic target for the
potential treatment of type 2 diabetes. The search for potent, selective and drug-like GP …

Photochemical mediated synthesis in organic chemistry is a highly expanding area. This is a
widely exploited area of research for the construction of new pharmaceutically significant …

Glycogen phosphorylase (GP) is a target for the treatment of hyperglycaemia in the context
of type 2 diabetes. This enzyme is responsible for the depolymerization of glycogen into …

Glucose derived inhibitors of glycogen phosphorylase - ScienceDirect Skip to main contentSkip
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1-(d-Glucopyranosyl)-1, 2, 3-triazoles were prepared from per-O-acetylated α-and β-d-
glucopyranosyl azides as well as per-O-benzoylated (β-d-gluco-hept-2-ulopyranosylazide) …

A series of glucopyranosylidene-spiro-isoxazolines was prepared through regio-and
stereoselective [3+ 2]-cycloaddition between the methylene acetylated exo-glucal and …

Among the variety of approaches for pharmacological intervention in T2DM, the inhibition of
GP with the aim of reducing hepatic glucose output is a validated and thoroughly …

Publisher Summary This chapter analyzes radical-mediated brominations at the ring
positions of carbohydrates. The radical-mediated bromination reactions of carbohydrate …

Acting generally as bio-precursors of isothiocyanates, glucosinolates (GLs) are important
thiosaccharidic metabolites which occur in all plant families of the order Brassicales–namely …

1,3-Dipolar cycloaddition of a chiral nitrone to (E)-1,4-dichloro-2-butene: a new efficient
synthesis of (2S,3S,4R)-4-hydroxyisoleucine - ScienceDirect Skip to main contentSkip to …