Immune System Dysregulation in the Progression of Multiple Sclerosis: Molecular Insights and Therapeutic Implications

Z Khan, S Mehan, GD Gupta, AS Narula - Neuroscience, 2024 - Elsevier
Multiple sclerosis (MS), a prevalent neurological disorder, predominantly affects young
adults and is characterized by chronic autoimmune activity. The study explores the immune …

Soluble CD27 is an intrathecal biomarker of T-cell-mediated lesion activity in multiple sclerosis

MT Cencioni, R Magliozzi, I Palmisano… - Journal of …, 2024 - Springer
Objective Soluble CD27 is a promising cerebrospinal fluid inflammatory biomarker in
multiple sclerosis. In this study, we investigate relevant immune and neuro-pathological …

Cerebrospinal Fluid Cytokine and Chemokine Profiles in Central Nervous System Sarcoidosis: Diagnostic and Immunopathologic Insights

G Mangioris, SJ Pittock, B Yang, JP Fryer… - Annals of …, 2024 - Wiley Online Library
Objective To evaluate the cerebrospinal fluid (CSF) cytokine/chemokine profile of central
nervous system (CNS) neurosarcoidosis (NS), and its utility in differential diagnosis …

Chemokine-mediated cell migration into the central nervous system in progressive multifocal leukoencephalopathy

M Deffner, T Schneider-Hohendorf… - Cell Reports …, 2024 - cell.com
Progressive multifocal leukoencephalopathy (PML) has been associated with different forms
of immune compromise. This study analyzes the chemokine signals and attracted immune …