Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Non-surgical management of knee osteoarthritis: comparison of ESCEO and OARSI 2019 guidelines

NK Arden, TA Perry, RR Bannuru, O Bruyère… - Nature Reviews …, 2021 - nature.com
Knee osteoarthritis (OA) is a heterogeneous disease associated with substantial effects on
quality of life, and its clinical management is difficult. Among the several available guidelines …

Osteoarthritis: pathology, diagnosis, and treatment options

B Abramoff, FE Caldera - Medical Clinics, 2020 - medical.theclinics.com
Osteoarthritis (OA) is endemic throughout the world. An estimated 30.8 million adults in the
United States and 300 million individuals worldwide are living with OA. 1, 2 It is the leading …

[HTML][HTML] OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis

RR Bannuru, MC Osani, EE Vaysbrot, NK Arden… - Osteoarthritis and …, 2019 - Elsevier
Objective To update and expand upon prior Osteoarthritis Research Society International
(OARSI) guidelines by developing patient-focused treatment recommendations for …

[HTML][HTML] The burden of OA-health services and economics

VP Leifer, JN Katz, E Losina - Osteoarthritis and cartilage, 2022 - Elsevier
Osteoarthritis (OA) is a highly prevalent and disabling condition that affects over 7% of
people globally (528 million people). Prevalence levels are even higher in countries with …

Mesenchymal stem cells: amazing remedies for bone and cartilage defects

P Kangari, T Talaei-Khozani… - Stem Cell Research & …, 2020 - Springer
Skeletal disorders are among the leading debilitating factors affecting millions of people
worldwide. The use of stem cells for tissue repair has raised many promises in various …

Failure of cartilage regeneration: emerging hypotheses and related therapeutic strategies

S Muthu, JV Korpershoek, EJ Novais… - Nature Reviews …, 2023 - nature.com
Osteoarthritis (OA) is a disabling condition that affects billions of people worldwide and
places a considerable burden on patients and on society owing to its prevalence and …

Chondrocyte dedifferentiation and osteoarthritis (OA)

E Charlier, C Deroyer, F Ciregia, O Malaise… - Biochemical …, 2019 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage
degradation but also synovial membrane inflammation, osteophyte formation and …

CDC guideline for prescribing opioids for chronic pain—United States, 2016

D Dowell, TM Haegerich, R Chou - Jama, 2016 - jamanetwork.com
Importance Primary care clinicians find managing chronic pain challenging. Evidence of
long-term efficacy of opioids for chronic pain is limited. Opioid use is associated with serious …

The Warwick Agreement on femoroacetabular impingement syndrome (FAI syndrome): an international consensus statement

DR Griffin, EJ Dickenson, J O'donnell… - British journal of sports …, 2016 - bjsm.bmj.com
The 2016 Warwick Agreement on femoroacetabular impingement (FAI) syndrome was
convened to build an international, multidisciplinary consensus on the diagnosis and …