Pulmonary arterial hypertension (PAH) is a cardiopulmonary disease with high mortality. In
recent years, it has been recognized that PAH is a multi-organ system disease, involving the …

Metabolic syndrome (MS) is a growing disorder affecting thousands of people worldwide,
especially in industrialised countries, increasing mortality. Oxidative stress, hyperglycaemia …

Background Recent studies revealed that alterations in glucose and lipid metabolism in
idiopathic pulmonary arterial hypertension (IPAH) are associated with disease severity and …

Objectives. This study aims to correlate subclinical echocardiographic features with the
clinical, laboratory, and therapeutic profiles of the patients to characterize risks for systemic …

Pulmonary arterial hypertension (PAH) is a severe, multifactorial, and frequently
misdiagnosed disorder. The aim of this observational study was to compare the plasma and …

The impact of high-density lipoprotein (HDL) cholesterol on the development of
atherosclerosis and diseases of systemic circulation has been well documented both in …

Rationale The blood is a rich source of potential biomarkers for the diagnosis of idiopathic
and hereditary pulmonary arterial hypertension (iPAH and hPAH, referred to as “PAH”) …

Background Idiopathic pulmonary arterial hypertension (IPAH) patients are characterized by
elevated triglyceride (TG)-to-HDL cholesterol (HDL-C) ratio, which has been proposed to be …

Background Recently, we and others have reported a causal role for oxidized lipids in the
pathogenesis of pulmonary hypertension (PH). However, the role of low‐density lipoprotein …

Vascular inflammation critically regulates endothelial cell (EC) pathophenotypes, particularly
in pulmonary arterial hypertension (PAH). Dysregulation of lysosomal activity and …