[HTML][HTML] Nitrogen containing heterocycles as anticancer agents: a medicinal chemistry perspective
Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …
drugs are available on the market but they either lack specificity or have poor safety, severe …
[HTML][HTML] Quinoxaline: A comprehension of current pharmacological advancement in medicinal chemistry
SK Suthar, NS Chundawat, GP Singh… - European Journal of …, 2022 - Elsevier
Quinoxaline is a fused heterocycle ring template present in diverse pharmacophore and
widely used in medicinal chemistry. Owing to its vast pharmaceutical profile, several …
widely used in medicinal chemistry. Owing to its vast pharmaceutical profile, several …
Design, synthesis, docking, ADMET studies, and anticancer evaluation of new 3-methylquinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers
Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a critical role in cancer
angiogenesis. Inhibition of VEGFR-2 activity proved effective suppression of tumour …
angiogenesis. Inhibition of VEGFR-2 activity proved effective suppression of tumour …
[HTML][HTML] Novel synthetic routes to prepare biologically active quinoxalines and their derivatives: A synthetic review for the last two decades
H Khatoon, E Abdulmalek - Molecules, 2021 - mdpi.com
Quinoxalines, a class of N-heterocyclic compounds, are important biological agents, and a
significant amount of research activity has been directed towards this class. They have …
significant amount of research activity has been directed towards this class. They have …
Recent advances in the transition metal catalyzed synthesis of quinoxalines: a review
Quinoxalines are a class of N-heterocycles which are present in a variety of natural and
synthetic compounds. They act as a versatile building block in synthesizing novel …
synthetic compounds. They act as a versatile building block in synthesizing novel …
Novel quinoxaline-based VEGFR-2 inhibitors to halt angiogenesis
MMF Ismail, TZ Shawer, RS Ibrahim, RM Allam… - Bioorganic …, 2023 - Elsevier
Vascular endothelial growth factor receptor-2 is a dynamic target for therapeutic intervention
in various types of cancer. This study was aimed at exploring the VEGFR-2 inhibitory activity …
in various types of cancer. This study was aimed at exploring the VEGFR-2 inhibitory activity …
Identification of new [1, 2, 4] triazolo [4, 3-a] quinoxalines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, anticancer evaluation, and in silico studies
Tumor angiogenesis is mainly regulated by VEGFR-2. In this study, a new series of [1, 2, 4]
triazolo [4, 3-a] quinoxaline based-derivatives has been designed and synthesized to …
triazolo [4, 3-a] quinoxaline based-derivatives has been designed and synthesized to …
Ultrasonic energy for construction of bioactive heterocycles
The ultrasonic energy has been revisited and applied for the synthesis of bioactive
molecules in a short time and green method. These compounds can exhibit anticancer …
molecules in a short time and green method. These compounds can exhibit anticancer …
[HTML][HTML] Synthesis of novel antibacterial and antifungal quinoxaline derivatives
X Tang, Q Zhou, W Zhan, D Hu, R Zhou, N Sun… - RSC …, 2022 - pubs.rsc.org
A series of quinoxaline derivatives were designed, synthesized and evaluated as
antimicrobial agents against plant pathogenic bacteria and fungi. Some of these compounds …
antimicrobial agents against plant pathogenic bacteria and fungi. Some of these compounds …
Quinoxaline derivatives as a promising scaffold for breast cancer treatment
RRE Eldin, AA Al-Karmalawy, MH Alotaibi… - New Journal of …, 2022 - pubs.rsc.org
According to Global Cancer Statistics 2021, female breast cancer has exceeded lung cancer
as the most frequently diagnosed cancer. As a result of this widespread breast cancer, it is …
as the most frequently diagnosed cancer. As a result of this widespread breast cancer, it is …