[HTML][HTML] Nitrogen containing heterocycles as anticancer agents: a medicinal chemistry perspective

A Kumar, AK Singh, H Singh, V Vijayan, D Kumar… - Pharmaceuticals, 2023 - mdpi.com
Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …

[HTML][HTML] Quinoxaline: A comprehension of current pharmacological advancement in medicinal chemistry

SK Suthar, NS Chundawat, GP Singh… - European Journal of …, 2022 - Elsevier
Quinoxaline is a fused heterocycle ring template present in diverse pharmacophore and
widely used in medicinal chemistry. Owing to its vast pharmaceutical profile, several …

Design, synthesis, docking, ADMET studies, and anticancer evaluation of new 3-methylquinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers

MM Alanazi, IH Eissa, NA Alsaif… - Journal of Enzyme …, 2021 - Taylor & Francis
Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a critical role in cancer
angiogenesis. Inhibition of VEGFR-2 activity proved effective suppression of tumour …

[HTML][HTML] Novel synthetic routes to prepare biologically active quinoxalines and their derivatives: A synthetic review for the last two decades

H Khatoon, E Abdulmalek - Molecules, 2021 - mdpi.com
Quinoxalines, a class of N-heterocyclic compounds, are important biological agents, and a
significant amount of research activity has been directed towards this class. They have …

Recent advances in the transition metal catalyzed synthesis of quinoxalines: a review

VK Maikhuri, AK Prasad, A Jha… - New Journal of Chemistry, 2021 - pubs.rsc.org
Quinoxalines are a class of N-heterocycles which are present in a variety of natural and
synthetic compounds. They act as a versatile building block in synthesizing novel …

Novel quinoxaline-based VEGFR-2 inhibitors to halt angiogenesis

MMF Ismail, TZ Shawer, RS Ibrahim, RM Allam… - Bioorganic …, 2023 - Elsevier
Vascular endothelial growth factor receptor-2 is a dynamic target for therapeutic intervention
in various types of cancer. This study was aimed at exploring the VEGFR-2 inhibitory activity …

Identification of new [1, 2, 4] triazolo [4, 3-a] quinoxalines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, anticancer evaluation, and in silico studies

NA Alsaif, MS Taghour, MM Alanazi… - Bioorganic & Medicinal …, 2021 - Elsevier
Tumor angiogenesis is mainly regulated by VEGFR-2. In this study, a new series of [1, 2, 4]
triazolo [4, 3-a] quinoxaline based-derivatives has been designed and synthesized to …

Ultrasonic energy for construction of bioactive heterocycles

O Kamble, R Chatterjee, R Dandela, S Shinde - Tetrahedron, 2022 - Elsevier
The ultrasonic energy has been revisited and applied for the synthesis of bioactive
molecules in a short time and green method. These compounds can exhibit anticancer …

[HTML][HTML] Synthesis of novel antibacterial and antifungal quinoxaline derivatives

X Tang, Q Zhou, W Zhan, D Hu, R Zhou, N Sun… - RSC …, 2022 - pubs.rsc.org
A series of quinoxaline derivatives were designed, synthesized and evaluated as
antimicrobial agents against plant pathogenic bacteria and fungi. Some of these compounds …

Quinoxaline derivatives as a promising scaffold for breast cancer treatment

RRE Eldin, AA Al-Karmalawy, MH Alotaibi… - New Journal of …, 2022 - pubs.rsc.org
According to Global Cancer Statistics 2021, female breast cancer has exceeded lung cancer
as the most frequently diagnosed cancer. As a result of this widespread breast cancer, it is …