Precision medicine in human heart modeling: perspectives, challenges, and opportunities
Precision medicine is a new frontier in healthcare that uses scientific methods to customize
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …
[HTML][HTML] Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies
Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …
The 'Digital Twin'to enable the vision of precision cardiology
J Corral-Acero, F Margara, M Marciniak… - European heart …, 2020 - academic.oup.com
Providing therapies tailored to each patient is the vision of precision medicine, enabled by
the increasing ability to capture extensive data about individual patients. In this position …
the increasing ability to capture extensive data about individual patients. In this position …
[HTML][HTML] A comprehensive and biophysically detailed computational model of the whole human heart electromechanics
While ventricular electromechanics is extensively studied in both physiological and
pathological conditions, four-chamber heart models have only been addressed recently; …
pathological conditions, four-chamber heart models have only been addressed recently; …
A mathematical model that integrates cardiac electrophysiology, mechanics, and fluid dynamics: Application to the human left heart
We propose a mathematical and numerical model for the simulation of the heart function that
couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and …
couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and …
Advancing regulatory science with computational modeling for medical devices at the FDA's Office of Science and Engineering Laboratories
TM Morrison, P Pathmanathan, M Adwan… - Frontiers in …, 2018 - frontiersin.org
Protecting and promoting public health is the mission of the US Food and Drug
Administration (FDA). FDA's Center for Devices and Radiological Health (CDRH), which …
Administration (FDA). FDA's Center for Devices and Radiological Health (CDRH), which …
The physics of heart rhythm disorders
WJ Rappel - Physics reports, 2022 - Elsevier
The global burden caused by cardiovascular disease is substantial, with heart disease
representing the most common cause of death around the world. There remains a need to …
representing the most common cause of death around the world. There remains a need to …
Calibration of ionic and cellular cardiac electrophysiology models
Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …
mathematical models of biological systems. This maturity is bringing new challenges as …
Hemodynamic modeling, medical imaging, and machine learning and their applications to cardiovascular interventions
Cardiovascular disease is a deadly global health crisis that carries a substantial financial
burden. Innovative treatment and management of cardiovascular disease straddles …
burden. Innovative treatment and management of cardiovascular disease straddles …
The critical role of lumped parameter models in patient-specific cardiovascular simulations
Cardiovascular (CV) disease impacts tens of millions of people annually and carries a
massive global economic burden. Continued advances in medical imaging, hardware and …
massive global economic burden. Continued advances in medical imaging, hardware and …