Macrophages phagocytize pathogens to initiate innate immunity and products from the
tumor microenvironment (TME) to mediate tumor immunity. The loss of tumor-associated …

An appropriate control over cell cycle progression depends on many factors. Cyclin-
dependent kinase (CDK) inhibitor p21 (also known as p21 WAF1/Cip1) is one of these …

Eicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that
have been implicated in various pathological processes, such as inflammation and cancer …

Technological and computational advances in genomics and interactomics have made it
possible to identify how disease mutations perturb protein–protein interaction (PPI) networks …

Arachidonic acid can be oxygenated by a variety of different enzymes, including
lipoxygenases, cyclooxygenases, and cytochrome P450s, and can be converted to a …

Increasing evidence from epidemiological, preclinical and clinical studies suggests that
dysregulated inflammatory response plays a pivotal role in a multitude of chronic ailments …

Melatonin is a neurohormone produced by the pineal gland that regulates sleep and
circadian functions. Melatonin also regulates inflammatory and immune processes acting as …

Inflammation in the tumor microenvironment is now recognized as one of the hallmarks of
cancer. Endogenously produced lipid autacoids, locally acting small molecule lipid …

Lipoxygenases (LOXs) are lipid peroxidizing enzymes, implicated in the pathogenesis of
inflammatory and hyperproliferative diseases, which represent potential targets for …

Lipoxygenases (LOX) form a family of lipid peroxidizing enzymes, which have been
implicated in a number of physiological processes and in the pathogenesis of inflammatory …