Sequence-specific RNA-binding proteins (RBPs) bind to pre-mRNA to control alternative
splicing, but it is not yet possible to read the'splicing code'that dictates splicing regulation on …

The intron–exon architecture of many eukaryotic genes raises the intriguing question of
whether this unique organization serves any function, or is it simply a result of the spread of …

SR proteins are well-characterized RNA binding proteins that promote exon inclusion by
binding to exonic splicing enhancers (ESEs). However, it has been unclear whether …

Similar to many genes involved in programmed cell death (PCD), the caspase 2 (casp-2)
gene generates both proapoptotic and antiapoptotic isoforms by alternative splicing. Using a …

Protein-coding sequences make up only about 1% of the mammalian genome. Much of the
remaining 99% has been long assumed to be junk DNA, with little or no functional …

All eukaryotic genomes have genes with introns in variable sizes. As far as spliceosomal
introns are concerned, there are at least three basic parameters to stratify introns across …

Abstract The 3′ untranslated regions (3′ UTRs) of transcripts serve as important hubs for
posttranscriptional gene expression regulation. Here, we find that the exonisation of …

During terminal erythropoiesis, the splicing machinery in differentiating erythroblasts
executes a robust intron retention (IR) program that impacts expression of hundreds of …

One therapeutic approach to Duchenne Muscular Dystrophy (DMD) recently entering clinical
trials aims to convert DMD phenotypes to that of a milder disease variant, Becker Muscular …

Deep intron space harbors a diverse array of splicing regulatory elements that cooperate
with better‐known exon‐proximal elements to enforce proper tissue‐specific and …