Towards clinical translation of FLASH radiotherapy
MC Vozenin, J Bourhis, M Durante - Nature Reviews Clinical Oncology, 2022 - nature.com
The ultimate goal of radiation oncology is to eradicate tumours without toxicity to non-
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …
[HTML][HTML] Reinventing radiobiology in the light of FLASH radiotherapy
CL Limoli, MC Vozenin - Annual Review of Cancer Biology, 2023 - annualreviews.org
Ultrahigh–dose rate FLASH radiotherapy (FLASH-RT) is a potentially paradigm-shifting
treatment modality that holds the promise of expanding the therapeutic index for nearly any …
treatment modality that holds the promise of expanding the therapeutic index for nearly any …
Radiobiology of the FLASH effect
AA Friedl, KM Prise, KT Butterworth… - Medical …, 2022 - Wiley Online Library
Radiation exposures at ultrahigh dose rates (UHDRs) at several orders of magnitude greater
than in current clinical radiotherapy (RT) have been shown to manifest differential …
than in current clinical radiotherapy (RT) have been shown to manifest differential …
Ultra‐high dose rate electron beams and the FLASH effect: from preclinical evidence to a new radiotherapy paradigm
In their seminal paper from 2014, Fauvadon et al. coined the term FLASH irradiation to
describe ultra‐high‐dose rate irradiation with dose rates greater than 40 Gy/s, which results …
describe ultra‐high‐dose rate irradiation with dose rates greater than 40 Gy/s, which results …
[HTML][HTML] FLASH radiotherapy: history and future
B Lin, F Gao, Y Yang, D Wu, Y Zhang, G Feng… - Frontiers in …, 2021 - frontiersin.org
The biological effects of radiation dose to organs at risk surrounding tumor target volumes
are a major dose-limiting constraint in radiotherapy. This can mean that the tumor cannot be …
are a major dose-limiting constraint in radiotherapy. This can mean that the tumor cannot be …
A potential revolution in cancer treatment: A topical review of FLASH radiotherapy
FLASH radiotherapy (RT) is a novel technique in which the ultrahigh dose rate (UHDR)(≥
40 Gy/s) is delivered to the entire treatment volume. Recent outcomes of in vivo studies …
40 Gy/s) is delivered to the entire treatment volume. Recent outcomes of in vivo studies …
Understanding the FLASH effect to unravel the potential of ultra-high dose rate irradiation
H Kacem, A Almeida, N Cherbuin… - International journal of …, 2022 - Taylor & Francis
A reemergence of research implementing radiation delivery at ultra-high dose rates
(UHDRs) has triggered intense interest in the radiation sciences and has opened a new field …
(UHDRs) has triggered intense interest in the radiation sciences and has opened a new field …
[HTML][HTML] First demonstration of the FLASH effect with ultrahigh dose rate high-energy X-rays
F Gao, Y Yang, H Zhu, JX Wang, D Xiao, Z Zhou… - Radiotherapy and …, 2022 - Elsevier
Purpose This study aimed to evaluate whether high-energy X-rays (HEXs) of the PARTER
(platform for advanced radiotherapy research) platform built on CTFEL (Chengdu THz Free …
(platform for advanced radiotherapy research) platform built on CTFEL (Chengdu THz Free …
Model studies of the role of oxygen in the FLASH effect
Current radiotherapy facilities are standardized to deliver dose rates around 0.1–0.4 Gy/s in
2 Gy daily fractions, designed to deliver total accumulated doses to reach the tolerance limit …
2 Gy daily fractions, designed to deliver total accumulated doses to reach the tolerance limit …
[HTML][HTML] Comparison of ultra-high versus conventional dose rate radiotherapy in a patient with cutaneous lymphoma
O Gaide, F Herrera, WJ Sozzi, PG Jorge, R Kinj… - Radiotherapy and …, 2022 - Elsevier
A patient with a cutaneous lymphoma was treated on the same day for 2 distinct tumors
using a 15 Gy single electron dose given in a dose rate of 0.08 Gy/second versus 166 …
using a 15 Gy single electron dose given in a dose rate of 0.08 Gy/second versus 166 …