The glymphatic system and waste clearance with brain aging: a review

H Benveniste, X Liu, S Koundal, S Sanggaard, H Lee… - Gerontology, 2019 - karger.com
The glymphatic system is a glial-dependent waste clearance pathway in the brain, in place
of lymphatic vessels, dedicated to drain away soluble waste proteins and metabolic …

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

A Louveau, BA Plog, S Antila, K Alitalo… - The Journal of …, 2017 - Am Soc Clin Investig
Recent discoveries of the glymphatic system and of meningeal lymphatic vessels have
generated a lot of excitement, along with some degree of skepticism. Here, we summarize …

Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia

LM Hablitz, HS Vinitsky, Q Sun, FF Stæger… - Science …, 2019 - science.org
The glymphatic system is responsible for brain-wide delivery of nutrients and clearance of
waste via influx of cerebrospinal fluid (CSF) alongside perivascular spaces and through the …

Understanding the role of the perivascular space in cerebral small vessel disease

R Brown, H Benveniste, SE Black… - Cardiovascular …, 2018 - academic.oup.com
Small vessel diseases (SVDs) are a group of disorders that result from pathological
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …

Glymphatic system dysfunction and sleep disturbance may contribute to the pathogenesis and progression of Parkinson's disease

A Massey, MK Boag, A Magnier, DPCF Bispo… - International journal of …, 2022 - mdpi.com
Parkinson's disease (PD) is a multisystem alpha-synucleinopathic neurodegenerative
disease and the most prevalent neurodegenerative disorder after Alzheimer's disease with a …

Impaired glymphatic transport in spontaneously hypertensive rats

KN Mortensen, S Sanggaard, H Mestre… - Journal of …, 2019 - Soc Neuroscience
The glymphatic system is a brainwide CSF transport system that uses the perivascular space
for fast inflow of CSF. Arterial pulsations are a major driver of glymphatic CSF inflow, and …

Current concepts in intracranial interstitial fluid transport and the glymphatic system: part I—anatomy and physiology

JM Klostranec, D Vucevic, KD Bhatia, HGJ Kortman… - Radiology, 2021 - pubs.rsna.org
Normal physiologic function of organs requires a circulation of interstitial fluid to deliver
nutrients and clear cellular waste products. Lymphatic vessels serve as collectors of this fluid …

Glymphatic system evaluation using diffusion tensor imaging in patients with traumatic brain injury

JH Park, YJ Bae, JS Kim, WS Jung, JW Choi, TH Roh… - Neuroradiology, 2023 - Springer
Purpose Glymphatic system dysfunction has been reported in animal models of traumatic
brain injury (TBI). This study aimed to evaluate the activity of the human glymphatic system …

Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans

S Murase, N Sakitani, T Maekawa, D Yoshino… - Nature Biomedical …, 2023 - nature.com
The mechanisms by which physical exercise benefits brain functions are not fully
understood. Here, we show that vertically oscillating head motions mimicking mechanical …

A clinical primer for the glymphatic system

LP Carlstrom, A Eltanahy, A Perry, AA Rabinstein… - Brain, 2022 - academic.oup.com
The complex and dynamic system of fluid flow through the perivascular and interstitial
spaces of the CNS has new-found implications for neurological diseases. CSF movement …