The glymphatic system and waste clearance with brain aging: a review
The glymphatic system is a glial-dependent waste clearance pathway in the brain, in place
of lymphatic vessels, dedicated to drain away soluble waste proteins and metabolic …
of lymphatic vessels, dedicated to drain away soluble waste proteins and metabolic …
Understanding the functions and relationships of the glymphatic system and meningeal lymphatics
A Louveau, BA Plog, S Antila, K Alitalo… - The Journal of …, 2017 - Am Soc Clin Investig
Recent discoveries of the glymphatic system and of meningeal lymphatic vessels have
generated a lot of excitement, along with some degree of skepticism. Here, we summarize …
generated a lot of excitement, along with some degree of skepticism. Here, we summarize …
Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia
LM Hablitz, HS Vinitsky, Q Sun, FF Stæger… - Science …, 2019 - science.org
The glymphatic system is responsible for brain-wide delivery of nutrients and clearance of
waste via influx of cerebrospinal fluid (CSF) alongside perivascular spaces and through the …
waste via influx of cerebrospinal fluid (CSF) alongside perivascular spaces and through the …
Understanding the role of the perivascular space in cerebral small vessel disease
R Brown, H Benveniste, SE Black… - Cardiovascular …, 2018 - academic.oup.com
Small vessel diseases (SVDs) are a group of disorders that result from pathological
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …
Glymphatic system dysfunction and sleep disturbance may contribute to the pathogenesis and progression of Parkinson's disease
A Massey, MK Boag, A Magnier, DPCF Bispo… - International journal of …, 2022 - mdpi.com
Parkinson's disease (PD) is a multisystem alpha-synucleinopathic neurodegenerative
disease and the most prevalent neurodegenerative disorder after Alzheimer's disease with a …
disease and the most prevalent neurodegenerative disorder after Alzheimer's disease with a …
Impaired glymphatic transport in spontaneously hypertensive rats
The glymphatic system is a brainwide CSF transport system that uses the perivascular space
for fast inflow of CSF. Arterial pulsations are a major driver of glymphatic CSF inflow, and …
for fast inflow of CSF. Arterial pulsations are a major driver of glymphatic CSF inflow, and …
Current concepts in intracranial interstitial fluid transport and the glymphatic system: part I—anatomy and physiology
JM Klostranec, D Vucevic, KD Bhatia, HGJ Kortman… - Radiology, 2021 - pubs.rsna.org
Normal physiologic function of organs requires a circulation of interstitial fluid to deliver
nutrients and clear cellular waste products. Lymphatic vessels serve as collectors of this fluid …
nutrients and clear cellular waste products. Lymphatic vessels serve as collectors of this fluid …
Glymphatic system evaluation using diffusion tensor imaging in patients with traumatic brain injury
Purpose Glymphatic system dysfunction has been reported in animal models of traumatic
brain injury (TBI). This study aimed to evaluate the activity of the human glymphatic system …
brain injury (TBI). This study aimed to evaluate the activity of the human glymphatic system …
Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans
S Murase, N Sakitani, T Maekawa, D Yoshino… - Nature Biomedical …, 2023 - nature.com
The mechanisms by which physical exercise benefits brain functions are not fully
understood. Here, we show that vertically oscillating head motions mimicking mechanical …
understood. Here, we show that vertically oscillating head motions mimicking mechanical …
A clinical primer for the glymphatic system
LP Carlstrom, A Eltanahy, A Perry, AA Rabinstein… - Brain, 2022 - academic.oup.com
The complex and dynamic system of fluid flow through the perivascular and interstitial
spaces of the CNS has new-found implications for neurological diseases. CSF movement …
spaces of the CNS has new-found implications for neurological diseases. CSF movement …