Ischemic stroke is the leading cause of human disability and mortality in the world. The main
problem in stroke therapy is the search of efficient neuroprotector capable to rescue neurons …

Limonene is a monoterpene confined to the family of Rutaceae, showing several biological
properties such as antioxidant, anti-inflammatory, anticancer, antinociceptive and …

Ischemic stroke is a devastating disease and one of the leading causes of mortality
worldwide. Overproduction of reactive oxygen and nitrogen species (RONS) following …

The physiology of the vasculature in the central nervous system (CNS), which includes the
blood–brain barrier (BBB) and other factors, complicates the delivery of most drugs to the …

Neuroprotection for ischemic stroke refers to strategies, applied singly or in combination, that
antagonize the injurious biochemical and molecular events that eventuate in irreversible …

Elevating Akt activation is an obvious clinical strategy to prevent progressive neuronal death
in neurological diseases. However, this endeavor has been hindered because of the lack of …

The blood-brain barrier (BBB) is a vital component of the neurovascular unit (NVU)
containing tight junctional (TJ) proteins and different ion and nutrient transporters which …

Astrocytes limit inflammation after CNS injury, at least partially by physically containing it
within an astrocytic scar at the injury border. We report here that astrocytic transforming …

Stroke is a leading cause of death and disability in developed countries. N-methyl-D-
aspartate glutamate receptors (NMDARs) have important roles in stroke pathology and …

Stroke results in the disruption of tissue architecture and is the third leading cause of death
in the United States. Transplanting scaffolds containing stem cells into the injured areas of …