Heparan Sulfate Proteoglycans (HSPGs) are important cell surface and Extracellular Matrix
(ECM) maestros involved in the orchestration of multiple cellular events in physiology and …

The tumor microenvironment (TME) is composed of cancerous, non-cancerous, stromal, and
immune cells that are surrounded by the components of the extracellular matrix (ECM) …

Gastric cancer is one of the most aggressive cancers and is the second leading cause of
cancer death worldwide. Approximately 40% of global gastric cancer cases occur in China …

New York esophageal squamous cell carcinoma 1 (NY-ESO-1, CTAG1B) is a cancer-testis
antigen and currently a focus of several targeted immunotherapeutic strategies. We …

Background Due to the poor prognosis for advanced renal cell carcinoma (RCC), there is an
urgent need for new therapeutic targets and for prognostic markers to identify high risk …

Purpose: Chondrosarcomas are notoriously resistant to cytotoxic chemotherapeutic agents.
We sought to identify critical signaling pathways that contribute to their survival and …

Background Mutations in isocitrate dehydrogenase (IDH) 1 or-2 are found in~ 50% of
conventional central chondrosarcomas and in up to 87% of their assumed benign …

Osteoarthritis (OA) is a common degenerative joint disease, characterized by cartilage loss
and subchondral bone remodeling in response to abnormal mechanical load. Heparan …

Heparan sulfate (HS) is extensively expressed in cells, for example, cell membrane and
extracellular matrix of most mammalian cells and tissues, playing a key role in the growth …

The purpose of the present study was to investigate the clinical significance of the
expression of heparan sulfate 6‑O‑sulfotransferase 2 (HS6ST2) in gastric cancer (GC). The …